PMID: 25796970DOI: 10.1016/j.antiviral.2015.03.007Mar 24, 2015Paper
Targeting dengue virus NS4B protein for drug discovery
Antiviral Research
Xuping XiePei-Yong Shi
Abstract
The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
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