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Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

Organic & Biomolecular Chemistry

Nov 8, 2014

Rosa M SuárezJuan J Vaquero

Abstract

A library of azonia aromatic cations has been studied in order to gain insights into the effect of the size, shape and charge distribution on the fluorescence, DNA interactions and DNA sequence selectivity properties. Fluorescence-based thermal denaturation experiments, spectrofluorimet...read more

Mentioned in this Paper

Molecular Dynamics
In Vivo NMR Spectroscopy
Aromatic Amino Acid Decarboxylase Deficiency
RNA Denaturation
Fluorescence Spectroscopy
Mass Spectrometry
Cations
Aromatics
Denaturation
Circular Dichroism, Vibrational
Paper Details
References
  • References35
  • Citations4
1234
  • References35
  • Citations4

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Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

Organic & Biomolecular Chemistry

Nov 8, 2014

Rosa M SuárezJuan J Vaquero

PMID: 25378061

DOI: 10.1039/c4ob01465k

Abstract

A library of azonia aromatic cations has been studied in order to gain insights into the effect of the size, shape and charge distribution on the fluorescence, DNA interactions and DNA sequence selectivity properties. Fluorescence-based thermal denaturation experiments, spectrofluorimet...read more

Mentioned in this Paper

Molecular Dynamics
In Vivo NMR Spectroscopy
Aromatic Amino Acid Decarboxylase Deficiency
RNA Denaturation
Fluorescence Spectroscopy
Mass Spectrometry
Cations
Aromatics
Denaturation
Circular Dichroism, Vibrational

Related Papers

Nucleic Acids Symposium Series

Synthesis and DNA-binding of acridine-netropsin hybrid molecules

Nucleic Acids Symposium SeriesApril 26, 2000
Y KubotaR Uchida
Paper Details
References
  • References35
  • Citations4
1234
  • References35
  • Citations4
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