Apr 3, 2001

Targeting double stranded DNA with peptide nucleic acid (PNA)

Current Medicinal Chemistry
Peter E Nielsen

Abstract

PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.

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Mentioned in this Paper

Peptide Nucleic Acids
Mimic brand of tebufenozide
Future
Genetic Therapy, Somatic
Nucleic Acids
Nylons
Genetic Techniques
Vertebral Column
Osmolality
Entire Vertebral Column

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