Targeting EMT in Cancer with Repurposed Metabolic Inhibitors.

Trends in Cancer
Vignesh RameshPaolo Ceppi

Abstract

Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer, metastasis formation and chemoresistance, and therefore represents an attractive target in oncology. However, direct targeting of EMT effector molecules is, in most cases, pharmacologically challenging. Since emerging research has highlighted the distinct metabolic circuits involved in EMT, we propose the use of metabolism-specific inhibitors, FDA approved or under clinical trials, as a drug repurposing approach to target EMT in cancer. Metabolism-inhibiting drugs could be coupled with standard chemo- or immunotherapy to combat EMT-driven resistant and aggressive cancers.

Citations

Sep 13, 2020·Journal of Cellular and Molecular Medicine·Wanghao ChenLukui Chen
Sep 4, 2020·Micromachines·Lexi L CrowellTayloria N G Adams
Nov 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ghader BabaeiNasrin Zare Zavieyh Jaghi
Feb 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kittipong SanookpanPithi Chanvorachote
Apr 18, 2021·Journal of Cancer Research and Clinical Oncology·Hong-Li LiSai-Yang Zhang
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