Targeting Endothelial Ligands: ICAM-1/alicaforsen, MAdCAM-1

Journal of Crohn's & Colitis
Walter ReinischFabio Cataldi

Abstract

Specific blockade of the endothelial ligands intercellular adhesion molecule-1 [ICAM-1] and mucosal addressin cell adhesion molecule [MAdCAM] involved in leukocyte recruitment to the site of inflammation as therapeutic targets in inflammatory bowel disease [IBD] has been recognized from their overexpression in the inflamed mucosa and successful intervention based on these ligands in preclinical animal models. Interventions to target ICAM-1 in human IBD are confined to the ICAM-1 anti-sense oligonucleotide alicaforsen. While results with parenteral formulations of alicaforsen in Crohn's disease have largely been negative, efficacy signals derived from studies with an enema formulation in ulcerative colitis and pouchitis are promising and have led to a Food and Drug Administration Fast-Track designation for the latter. A large phase III programme in pouchitis is underway. Phase II studies with the anti-MAdCAM-1 antibody [SHP647] delivered positive results in ulcerative colitis and anti-inflammatory signals in Crohn's disease. Furthermore, it was shown that SHP647 does not affect the number and composition of cells in cerebrospinal fluid, suggesting that the compound is not affecting immune surveillance in the central nervous syst...Continue Reading

References

Sep 1, 1992·Gastroenterology·M KoizumiD K Podolsky
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·K J KellyJ V Bonventre
Mar 7, 1998·Clinical Immunology and Immunopathology·C N BernsteinW M Gallatin
Feb 12, 2000·Journal of Leukocyte Biology·S P BarrettI R van Driel
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Apr 21, 2001·Gastroenterology·S SchreiberUNKNOWN German ICAM-1 Study Group
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·T ShigematsuD N Granger
Apr 28, 2005·International Journal of Colorectal Disease·Stefan FarkasEdward K Geissler
Feb 25, 2006·Nature Reviews. Immunology·David H Adams, Bertus Eksteen
Aug 19, 2006·Inflammatory Bowel Diseases·Akira GotoYuji Hinoda
Feb 14, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bruce YacyshynEmil Chuang
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Apr 16, 2009·British Journal of Pharmacology·N PullenS Sreckovic
Oct 5, 2010·Current Gastroenterology Reports·Brian S Sheridan, Leo Lefrançois
Mar 21, 2012·The Journal of Experimental Medicine·Marie CherrierGérard Eberl
Jan 24, 2014·Clinical and Experimental Immunology·N-E SerriariE Treiner
Feb 1, 2014·Alimentary Pharmacology & Therapeutics·T LobatónP Rutgeerts
May 13, 2014·Expert Review of Clinical Immunology·Mariangela AlloccaSilvio Danese

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Citations

Nov 28, 2019·Cells·Edith Hintermann, Urs Christen
Apr 14, 2020·European Journal of Gastroenterology & Hepatology·Laura A LucaciuAndrada Seicean
May 10, 2019·Frontiers in Pharmacology·Patrizio ScarozzaRaja Atreya
May 28, 2020·Bioprocess and Biosystems Engineering·Wenshuo ChenJinlong Zhang
Feb 6, 2021·Cellular and Molecular Life Sciences : CMLS·Wan-Chi Lin, Michael B Fessler
Nov 8, 2020·Journal of Pharmaceutical Sciences·Shno AsadAlexandra Teleki
Sep 17, 2021·Journal of the American Medical Informatics Association : JAMIA·Lawrence BaiPurvesh Khatri
Jun 25, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Arya V S, Kanthlal S K

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