Targeting Epstein-Barr Virus in Nasopharyngeal Carcinoma

Frontiers in Oncology
Pok Man HauKwok Wai Lo

Abstract

Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV) infection in regions in which it is endemic, including Southern China and Southeast Asia. The high mortality rates of NPC patients with advanced and recurrent disease highlight the urgent need for effective treatments. While recent genomic studies have revealed few druggable targets, the unique interaction between the EBV infection and host cells in NPC strongly implies that targeting EBV may be an efficient approach to cure this virus-associated cancer. Key features of EBV-associated NPC are the persistence of an episomal EBV genome and the requirement for multiple viral latent gene products to enable malignant transformation. Many translational studies have been conducted to exploit these unique features to develop pharmaceutical agents and therapeutic strategies that target EBV latent proteins and induce lytic reactivation in NPC. In particular, inhibitors of the EBV latent protein EBNA1 have been intensively explored, because of this protein's essential roles in maintaining EBV latency and viral genome replication in NPC cells. In addition, recent advances in chemical bioengineering are driving the development of therapeutic agents targe...Continue Reading

References

Aug 1, 1992·Journal of Virology·E D FixmanS D Hayward
Mar 1, 1991·Journal of Virology·R F AmbinderS D Hayward
Oct 25, 2002·International Journal of Cancer. Journal International Du Cancer·Andrew Siu Chung ChanDolly Poon Huang
Dec 11, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jian-Hua LiFei-Fei Liu
Mar 10, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony T C ChanRichard F Ambinder
May 18, 2004·Cancer Cell·Kwok Wai LoDolly P Huang
Jun 15, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Marie C ChiaFei-Fei Liu
Sep 1, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kenneth W YipFei-Fei Liu
Sep 24, 2004·Reviews in Medical Virology·Tatsuya TsurumiAyumi Kudoh
Dec 28, 2004·Nature Medicine·Micah T McClainJudith A James
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeW H Lau
Apr 2, 2005·Cancer Gene Therapy·Zhong-Xin LuYa Cao
Jan 7, 2006·Nature Reviews. Cancer·Saverio Minucci, Pier Giuseppe Pelicci
Mar 16, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Joseph D MocanuFei-Fei Liu
Oct 24, 2008·The EMBO Journal·Julie NorseenPaul M Lieberman
Nov 21, 2008·Journal of Virology·Sebastien ApcherRobin Fåhraeus
Jan 10, 2009·International Journal of Cancer. Journal International Du Cancer·Chih-Yeu FangJen-Yang Chen
Oct 10, 2009·International Journal of Cancer. Journal International Du Cancer·K F Hui, Alan K S Chiang
Nov 10, 2009·Biological Trace Element Research·Saloua LassouedJos Van Pelt
Oct 12, 2010·Journal of Biomolecular Screening·Scott ThompsonPaul M Lieberman
Feb 8, 2011·Cancers·Joyce E Rundhaug, Susan M Fischer

❮ Previous
Next ❯

Citations

Jan 30, 2021·Frontiers in Microbiology·Juliette SavoretNathalie Chazal
Mar 26, 2021·International Immunopharmacology·Xiaoxu Li, Wenling Zhang
Jul 13, 2021·Frontiers in Molecular Biosciences·Shane BrennanOrla Sheils
Jul 2, 2021·Nature Reviews. Clinical Oncology·Kenneth C W WongAnthony T C Chan
Jul 2, 2021·Infectious Agents and Cancer·Francisco AguayoRancés Blanco
Dec 5, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Jingjing ShiPek-Lan Khong

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
X-ray
dot-blot
xenografts
transfection
histone acetylation
acetylation

Clinical Trials Mentioned

NCT03682055

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Sai Wah TsaoKwok Wai Lo
Japanese Journal of Clinical Oncology
Smriti M KrishnaPrabha Balaram
© 2022 Meta ULC. All rights reserved