PMID: 16613554Apr 15, 2006Paper

Targeting exocytosis: ins and outs of the modulation of quantal dopamine release

CNS & Neurological Disorders Drug Targets
Remco H S Westerink

Abstract

Dopaminergic neurotransmission is mediated by the vesicular release of dopamine (DA), i.e. DA exocytosis. DA exocytosis and its modulation are generally believed to affect neuronal communication, development, maintenance and survival, and contribute to extracellular DA levels in the brain. As a result, DA exocytosis likely plays an important role in several neurological and psychiatric disorders, like Parkinson's disease (PD) and schizophrenia. As exocytosis is part of a sophisticated ensemble of processes, it can be modulated at different levels, including DA synthesis, uptake and vesicular transport as well as Ca(2+)-homeostasis and exocytotic proteins. Nonetheless, to be effective, modulation of exocytosis should result in functional changes, which are reflected by changes in release frequency, vesicle contents, and the time course of the exocytotic event. As will be shown in this review, functional changes in DA exocytosis can be produced by e.g. pharmacological/drug treatment, feedback mechanisms and up/down-regulation of exocytosis-related proteins. Moreover, the mode of DA exocytosis, i.e. classical full fusion or kiss-and-run exocytosis, could also serve as a potential target for functional modulation of dopaminergic ne...Continue Reading

Citations

Dec 6, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Milou M L DingemansRemco H S Westerink
Jan 6, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wendy T LangeveldRemco H S Westerink
May 2, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hester S HendriksRemco H S Westerink
Nov 17, 2007·Acta Physiologica·R H S Westerink, A G Ewing
Feb 13, 2016·Environmental Toxicology and Pharmacology·Wenzhu WangLixu Liu
Nov 18, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martje W G D M de GrootRemco H S Westerink
May 4, 2016·Basal Ganglia·David SulzerMargaret E Rice
Jun 21, 2011·Toxicology and Applied Pharmacology·Harm J Heusinkveld, Remco H S Westerink
Apr 11, 2008·Brain Research·George E JaskiwRodolfo Bongiovanni
Jul 11, 2006·Journal of Neurochemistry·R H S WesterinkW J Wadman
Feb 16, 2011·Biophysical Journal·G Th H van KempenR H S Westerink
Sep 11, 2007·Biochemical Pharmacology·Leonard L Howell, Heather L Kimmel
Jul 19, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marieke MeijerRemco H S Westerink
Dec 1, 2010·European Journal of Pharmacology·Hironari KakoHidehiko Yokogoshi
Dec 7, 2007·Cellular Signalling·Márta SzaszákEnno Klussmann
Dec 17, 2014·The Veterinary Quarterly·Harm J HeusinkveldRemco H S Westerink
Apr 24, 2016·Toxicology Letters·Harm J HeusinkveldRemco H S Westerink
May 28, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Harm J HeusinkveldRemco H S Westerink
Jun 13, 2020·Critical Reviews in Toxicology·Deepika DeepikaVikas Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.