Targeting FcRn to Generate Antibody-Based Therapeutics

Trends in Pharmacological Sciences
E S Ward, Raimund J Ober

Abstract

The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen into antigen loading compartments in specialized antigen-presenting cells. In parallel with studies directed towards understanding FcRn at the molecular and cellular levels, there has been an enormous expansion in the development of engineering strategies involving FcRn to modulate the dynamic behavior of antibodies, antigens, and albumin. In this review article, we focus on a discussion of FcRn-targeted approaches that have resulted in the production of novel antibody-based platforms with considerable potential for use in the clinic.

Citations

Feb 8, 2019·Current Pharmaceutical Design·Huanbo TanPeijian Zou
Apr 24, 2019·The Journal of Pharmacology and Experimental Therapeutics·A R Satvik IyengarAbhay H Pande
Sep 24, 2019·Antibodies·Steven W de TaeyeGestur Vidarsson
Sep 27, 2019·Immunological Reviews·Liriye KurtovicJames G Beeson
Mar 14, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeong A Park, Nai-Kong V Cheung
Mar 12, 2020·Immunology and Cell Biology·Alicia M ChenowethP Mark Hogarth
Sep 12, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sawsan AlabbadHenry J Kaminski
Nov 19, 2019·Experimental & Molecular Medicine·Tae Hyun Kang, Sang Taek Jung
Jul 30, 2019·Frontiers in Immunology·Michal PyzikRichard S Blumberg
Jul 12, 2019·Frontiers in Immunology·Dario DidonaMichael Hertl
Oct 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sofia RossiniJordan D Dimitrov
Dec 19, 2020·Antibodies·Geert van TeteringJeanette Leusen
Sep 6, 2020·Biologicals : Journal of the International Association of Biological Standardization·Neungseon SeoJennifer Liu
Dec 29, 2020·Biochemical and Biophysical Research Communications·Guglielmo VescoTiziana Alberio
Dec 23, 2020·Scandinavian Journal of Immunology·Kristin Hovden AaenJan Terje Andersen
Jan 24, 2021·Journal of Biomedical Science·Tomasz Klaus, Sameer Deshmukh
Dec 31, 2020·Vaccines·Hans Van der WekenBert Devriendt
Sep 29, 2020·Journal of Neuroimmunology·Xiaoyu MaWei Qiu
Apr 23, 2021·Advanced Drug Delivery Reviews·Cláudia AzevedoBruno Sarmento
Apr 11, 2021·Journal of Crohn's & Colitis·Bella UngarShomron Ben Horin
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.