Targeting FMS-related tyrosine kinase receptor 3 with the human immunoglobulin G1 monoclonal antibody IMC-EB10

Cancer
Hagop YoussoufianYiwen Li

Abstract

FMS-related tyrosine kinase receptor 3 (FLT3) is a class III receptor tyrosine kinase that holds considerable promise as a therapeutic target in hematologic malignancies. Current efforts directed toward the development of small-molecule tyrosine kinase inhibitors of FLT3 may be limited by off-target toxicities and the development of drug resistance. Target-specific antibodies could overcome these hurdles and provide additional mechanisms to enhance the antitumor efficacy of FLT3 inhibitors. IMC-EB10 is a novel antibody directed against FLT3. The binding of IMC-EB10 to FLT3 results in antiproliferative effects in vitro and in mouse models engrafted with human leukemia cells that harbor wild-type or constitutively activated FLT3. Future clinical trials will test these notions formally and will identify the most appropriate opportunities for this member of a new generation of antileukemic therapies.

References

Aug 6, 2003·British Journal of Haematology·Panagiotis D KottaridisDavid C Linch
Sep 3, 2003·Nature Reviews. Cancer·Derek L Stirewalt, Jerald P Radich
Sep 13, 2003·Leukemia·M Levis, D Small
Sep 9, 2005·International Journal of Hematology·Mark Levis, Donald Small
Feb 21, 2007·Expert Opinion on Biological Therapy·Yiwen Li, Zhenping Zhu

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Citations

Oct 19, 2012·Nature Reviews. Cancer·Kenneth Verstraete, Savvas N Savvides
Jul 14, 2010·Oncogene·E WeisbergJ D Griffin
Dec 1, 2010·Asia-Pacific Journal of Clinical Oncology·Hemangini H VoraPankaj M Shah
Apr 4, 2021·Pharmacology & Therapeutics·Mohammed F AlmataniHouda Alachkar
Oct 1, 2010·Current Opinion in Rheumatology

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