Targeting friend and foe: Emerging therapeutics in the age of gut microbiome and disease

The Journal of Microbiology
Jin Ah Cho, Daniel J F Chinnapen

Abstract

Mucosal surfaces that line our gastrointestinal tract are continuously exposed to trillions of bacteria that form a symbiotic relationship and impact host health and disease. It is only beginning to be understood that the cross-talk between the host and microbiome involve dynamic changes in commensal bacterial population, secretion, and absorption of metabolites between the host and microbiome. As emerging evidence implicates dysbiosis of gut microbiota in the pathology and progression of various diseases such as inflammatory bowel disease, obesity, and allergy, conventional treatments that either overlook the microbiome in the mechanism of action, or eliminate vast populations of microbes via wide-spectrum antibiotics need to be reconsidered. It is also becoming clear the microbiome can influence the body's response to therapeutic treatments for cancers. As such, targeting the microbiome as treatment has garnered much recent attention and excitement from numerous research labs and biotechnology companies. Treatments range from fecal microbial transplantation to precision-guided molecular approaches. Here, we survey recent progress in the development of innovative therapeutics that target the microbiome to treat disease, and hi...Continue Reading

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Citations

Mar 2, 2018·The Journal of Microbiology·Woojun Park
Sep 4, 2019·The ISME Journal·Kaitlyn OliphantEmma Allen-Vercoe
Apr 27, 2019·Frontiers in Immunology·Renata CurciarelloCecilia Isabel Muglia
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May 22, 2021·Experimental & Molecular Medicine·Jong-Hwa KimWonyong Kim
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Priti TagdeMohamed M Abdel-Daim
Oct 24, 2018·Journal of Chemical Information and Modeling·Suqing ZhengFu Lin

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