journal cover

Targeting genes in living mammals by RNA interference

Briefings in Functional Genomics

Jul 9, 2011

Katerina Podolska, Petr Svoboda

Abstract

More than a decade has passed since the discovery of RNA interference (RNAi), an eukaryotic sequence-specific degradation of mRNA induced by complementary double-stranded RNA (dsRNA). RNAi became a common tool for controlled down-regulation of gene expression in cultured cells, as well ...read more

Mentioned in this Paper

Gene Knockdown Techniques
Cosuppression
RNA, Double-Stranded
Genetic Therapy, Somatic
Transgenes
Cells, Cultured [Chemical/Ingredient]
Catabolism
RNA Interference
1
27
Paper Details
References
  • References87
  • Citations7
12345...
  • References87
  • Citations7
1

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Targeting genes in living mammals by RNA interference

Briefings in Functional Genomics

Jul 9, 2011

Katerina Podolska, Petr Svoboda

PMID: 21737416

DOI: 10.1093/bfgp/elr013

Abstract

More than a decade has passed since the discovery of RNA interference (RNAi), an eukaryotic sequence-specific degradation of mRNA induced by complementary double-stranded RNA (dsRNA). RNAi became a common tool for controlled down-regulation of gene expression in cultured cells, as well ...read more

Mentioned in this Paper

Gene Knockdown Techniques
Cosuppression
RNA, Double-Stranded
Genetic Therapy, Somatic
Transgenes
Cells, Cultured [Chemical/Ingredient]
Catabolism
RNA Interference
1
27

Similar Papers Found In These Feeds

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

International Journal of Biological Sciences

RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector

International Journal of Biological SciencesFebruary 17, 2007
Vivek ShuklaChu-Xia Deng
Biochemical and Biophysical Research Communications

Long-term RNA interference from optimized siRNA expression constructs in adult mice

Biochemical and Biophysical Research CommunicationsJuly 5, 2005
Christine I WooddellHans Herweijer
Paper Details
References
  • References87
  • Citations7
12345...
  • References87
  • Citations7
1
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