Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy

Biomaterials
Cong-Fei XuJun Wang

Abstract

Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we report an effective strategy for cancer therapy through targeting glucose transporter 3 (GLUT3) with siRNA-based nanomedicine to simultaneously inhibit the self-renewal of glioma stem cells and bulk glioma cells in a glucose restricted tumor micro-environment. We have demonstrated that cationic lipid-assisted poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PLA) nanoparticles can efficiently deliver siRNA into U87MG and U251 glioma stem cells and bulk glioma cells. Nanoparticles carrying specific siRNA targeting GLUT3 (NPsiGLUT3) were able to significantly reduce the expression of GLUT3 in glioma stem cells and bulk glioma cells, while GLUT3 knockdown results in obvious cell metabolism and proliferation inhibition, and further glioma stem cells percentage down-regulation. Moreover, systemic delivery of NPsiGLUT3, via intravenous injection, significantly inhibited tumor growth in a U87MG xenograft model, due to the reduced expression of GLUT3 and down-regulated stemness of glioma...Continue Reading

References

Jun 1, 1990·Diabetes Care·B B Kahn, J S Flier
Feb 1, 1987·The Journal of Clinical Investigation·J S FlierH F Lodish
Feb 1, 1994·European Journal of Biochemistry·M Mueckler
Sep 5, 2002·Nature Reviews. Cancer·Sanjiv Sam Gambhir
Jan 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Feng QinDavid Baltimore
May 13, 2003·Nature Biotechnology·Anton P McCaffreyMark A Kay
Aug 10, 1956·Science·O WARBURG
Sep 17, 2004·Nature·Gregory J Hannon, John J Rossi
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
May 24, 2005·Nature Biotechnology·Erwei SongJudy Lieberman
Mar 28, 2006·Nature·Tracy S ZimmermannIan MacLachlan
Jun 15, 2007·Journal of Cellular Physiology·Ana Maria MenesesGareth I Owen
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Jun 26, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ian A SimpsonSusan J Vannucci
Mar 27, 2009·Carcinogenesis·Daniel A TennantEyal Gottlieb
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Nov 4, 2009·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hwan Jun JaeJae Hyung Park
Jan 19, 2010·Nature Biotechnology·Sean C SempleMichael J Hope
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne LeChi V Dang
Mar 10, 2011·Nature Medicine·Hans Clevers
Jun 7, 2011·Annual Review of Biomedical Engineering·Leaf Huang, Yang Liu
Aug 2, 2011·Nature Genetics·Jason W LocasaleMatthew G Vander Heiden
Aug 5, 2011·Science Translational Medicine·Denise A ChanAmato J Giaccia
Aug 16, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xian-Zhu YangJun Wang
Sep 1, 2011·Nature Reviews. Drug Discovery·Matthew G Vander Heiden
Jan 13, 2012·Nature Reviews. Cancer·Long V NguyenConnie J Eaves
Apr 21, 2012·Science Translational Medicine·Yan-dan YaoErwei Song
Jun 28, 2012·Molecular Systems Biology·Nicholas A GrahamThomas G Graeber
Aug 24, 2012·Current Opinion in Oncology·Kehinde AdekolaMala Shanmugam
Oct 30, 2012·Molecular Cell·Laura A Sena, Navdeep S Chandel
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tomoko AkahaneDaisuke Aoki
Dec 26, 2012·Biochimica Et Biophysica Acta·Leszek Szablewski
Sep 3, 2013·Nature Neuroscience·William A FlavahanAnita B Hjelmeland
Sep 26, 2013·Nature Reviews. Cancer·Benjamin Beck, Cédric Blanpain

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Citations

Aug 16, 2015·Targeted Oncology·Francesca PistollatoMaurizio Battino
Oct 5, 2015·Biomaterials·Song ShenJun Wang
Mar 5, 2016·FEBS Letters·Elizabeth M SelwanAimee L Edinger
Apr 19, 2016·Molecular Therapy. Methods & Clinical Development·Jie ChenXuesi Chen
Feb 6, 2017·Frontiers in Pharmacology·Weiwei QinYuanqing Zhang
Nov 25, 2017·Journal of Drug Targeting·Leila FarahmandKeivan Majidzadeh-A
Dec 13, 2017·Oncotarget·Swetlana SperlingMilena Ninkovic
Aug 9, 2017·Frontiers in Molecular Biosciences·Vimal K SinghRamesh Chandra
Mar 10, 2020·Advanced Drug Delivery Reviews·Hao TangXingyu Jiang
Dec 31, 2020·Cancers·Elia BozzatoVéronique Préat
Jul 3, 2021·Frontiers in Cell and Developmental Biology·Runze QiuHongwei Fan

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