Targeting granulocyte apoptosis: mechanisms, models, and therapies.

Immunological Reviews
R DuffinAdriano G Rossi

Abstract

The inflammatory process is a complex series of tightly controlled cellular and biochemical events initiated by the immune system, which has evolved to eliminate or contain infectious agents and to repair damaged tissue. Apoptosis is essential for the clearance of potentially injurious inflammatory cells, such as neutrophils, eosinophils, and basophils, and the subsequent efficient resolution of inflammation. In this review, we aim to cover key features of the granulocyte life-cycle ranging from their differentiation within the bone marrow to their maturation and ultimate clearance, with a focus on granulocyte apoptosis and macrophage efferocytosis. We further aim to discuss current and emerging models of inflammation and suggest novel ways of terminating or resolving deleterious inflammatory responses with a specific view to the translation of these strategies into fully realized, pro-resolution therapies.

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Citations

Dec 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher D LucasAdriano G Rossi
Nov 30, 2011·TheScientificWorldJournal·David M GoncalvesDenis Girard
Jan 28, 2012·American Journal of Respiratory Cell and Molecular Biology·Hong-Beom BaeEdward Abraham
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Mar 14, 2013·La Presse médicale·Véronique Witko-Sarsat
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Mar 3, 2018·International Journal of Molecular Sciences·Simone WickiThomas Kaufmann
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Jun 24, 2011·Journal of Leukocyte Biology·Karin ChristensonJohan Bylund
Mar 1, 2014·Journal of Leukocyte Biology·Larissa DyugovskayaLena Lavie

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