Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence

Translational Research : the Journal of Laboratory and Clinical Medicine
Alessandro FedericoFederico Salomone

Abstract

Nonalcoholic fatty liver disease (NAFLD) is widely emerging as the most prevalent liver disorder and is associated with increased risk of liver-related and cardiovascular mortality. Recent experimental and clinical studies have revealed the pivotal role played by the alteration of gut-liver axis in the onset of fatty liver and related metabolic disturbances. Gut-liver cross talk is implicated not only in the impairment of lipid and glucose homeostasis leading to steatogenesis, but also in the initiation of inflammation and fibrogenesis, which characterize nonalcoholic steatohepatitis (NASH), the evolving form of NAFLD. The gut microbiota has been recognized as the key player in the gut-liver liaison and because of its complexity can act as a villain or a victim. Gut microbiota not only influences absorption and disposal of nutrients to the liver, but also conditions hepatic inflammation by supplying toll-like receptor ligands, which can stimulate liver cells to produce proinflammatory cytokines. Thus, the modification of intestinal bacterial flora by specific probiotics has been proposed as a therapeutic approach for the treatment of NASH. In this review, we summarized the evidence regarding the role of gut-liver axis in the pa...Continue Reading

References

Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A RimolaJ Rodes
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E FerreroS M Goyert
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Nov 1, 1996·Trends in Microbiology·R D Berg
Sep 23, 1997·Scandinavian Journal of Gastroenterology·C C ChanS D Lee
Apr 18, 1998·Gastroenterology·C P Day, O F James
Nov 18, 2000·The New England Journal of Medicine·H Tilg, A M Diehl
Mar 14, 2001·Trends in Biochemical Sciences·J O Thomas, A A Travers
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Jul 11, 2002·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jukka-Pekka VisapääMikko Salaspuro
Sep 7, 2002·The British Journal of Nutrition·C A Edwards, A M Parrett
Nov 1, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P GionchettiM Campieri
Nov 1, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Roberfroid
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vicente Lorenzo-ZúñigaMiquel Angel Gassull
Apr 26, 2003·Journal of Hepatology·Steven F Solga, A M Diehl
Nov 19, 2003·Scandinavian Journal of Gastroenterology·R SadikP O Stotzer
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Oct 12, 2004·Inflammatory Bowel Diseases·Robin L Jump, Alan D Levine
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Jun 9, 2005·Journal of Clinical Gastroenterology·Carmela LoguercioCamillo Del Vecchio Blanco
Nov 17, 2005·Annals of Internal Medicine·Masahide HamaguchiKazunori Ida
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·Gyongyi SzaboPranoti Mandrekar
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vito Racanelli, Barbara Rehermann
Feb 25, 2006·Scandinavian Journal of Gastroenterology·Evangelos KalaitzakisEinar Björnsson
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Jun 6, 2006·Cell·Katherine A Fitzgerald, Zhijian J Chen
Jul 21, 2006·American Journal of Physiology. Cell Physiology·Charles W BellDavid S Pisetsky
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Apr 26, 2007·Nature Reviews. Immunology·Luke A J O'Neill, Andrew G Bowie
May 17, 2007·Journal of Gastroenterology and Hepatology·Jing HuaYan Sheng Peng
Oct 24, 2007·Nature Medicine·Ekihiro SekiRobert F Schwabe

❮ Previous
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Citations

Feb 26, 2016·Frontiers in Physiology·Ping WangTatiana Kisseleva
Feb 5, 2016·Digestive Diseases and Sciences·Marco ArreseAriel E Feldstein
Jun 4, 2016·Nature Reviews. Rheumatology·Shahla Abdollahi-RoodsazJose U Scher
Jan 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandro FedericoCarmelina Loguercio
Jan 22, 2017·Journal of Hepatology·Eva-Carina HeierVeronika Lukacs-Kornek
Apr 4, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Shira Zelber-SagiLiat Mlynarsky
May 3, 2016·Therapeutic Advances in Gastroenterology·Shira Zelber-SagiFederico Salomone
Jun 28, 2017·World Journal of Hepatology·Mark Benedict, Xuchen Zhang
Jun 9, 2016·Nature Reviews. Gastroenterology & Hepatology·Christopher LeungPeter W Angus
May 8, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Catherine ProperziLeon A Adams
Mar 25, 2019·Nutrients·Carolina M PerdomoJavier Escalada
Aug 17, 2019·Phytotherapy Research : PTR·Jacqueline Ruiz-CanizalesGustavo A González-Aguilar
Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
Feb 24, 2016·Nutrition & Metabolism·Nazarii KobyliakPeter Kruzliak
Dec 6, 2016·World Journal of Hepatology·Safak Kiziltas
Nov 23, 2017·The New England Journal of Medicine·Anna M Diehl, Christopher Day
Jan 31, 2019·Frontiers in Physiology·Marianela González-GonzálezMarcela Julio-Pieper
Nov 11, 2019·Reviews in Endocrine & Metabolic Disorders·Marc Schoeler, Robert Caesar
Aug 31, 2019·International Journal of Environmental Research and Public Health·Marcello DallioAlessandro Federico
Jan 31, 2021·Annals of Hepatology·Chanthawat PatikornNathorn Chaiyakunapruk
Jan 19, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Waleska Dornas, Vincent Lagente
Jun 2, 2021·Cellular and Molecular Gastroenterology and Hepatology·Souradipta GangulyDebanjan Dhar
Nov 27, 2018·Analytical Chemistry·Jong Hwan SungMichael L Shuler

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