Targeting Hepatitis D

Seminars in Liver Disease
M Rizzetto

Abstract

New therapeutic strategies to treat chronic hepatitis D are directed to deprive the hepatitis D virus (HDV) of functions necessary to complete its life cycle that are provided by the hepatitis B virus (HBV) and by the host. Current options are (1) the block by the synthetic peptide Myrcludex B of HBV surface antigen (HBsAg) entry into cells through the inhibition of the sodium taurocholate cotransporting receptor; (2) the inhibition with lonafarnib of the farnesylation of the large HD antigen, required for virion assembly; (3) the presumed reduction by the nucleic acid polymer REP 2139 of the release of the HBsAg and subviral HBV particles necessary for HD virion morphogenesis. Lonafarnib and Myrcludex in monotherapy reduced serum HDV-RNA but did not reduce the HBsAg and HD viremia rebounded after therapy; they may provide additional efficacy to pegylated interferon alpha (Peg IFN-α) therapy. Treatment with REP-2139 in combination with Peg IFN-α induced a sustained clearance both of the HDV-RNA and HBsAg in 5 of 12 patients, providing the best interim results so far obtained in the therapy of chronic hepatitis D.

Citations

May 10, 2018·European Journal of Gastroenterology & Hepatology·Antonio AguileraVicente Soriano
Jan 21, 2019·Journal of Viral Hepatitis·Parag MahaleThomas R O'Brien
Oct 15, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Karlla A A CaetanoSheila A Teles
Oct 26, 2018·TheScientificWorldJournal·Mohamed A DawIbrahem M Daw
Jul 19, 2019·Journal of Paediatrics and Child Health·Winita Hardikar
Jan 24, 2021·Journal of Hepatology·Mario RizzettoFranco Negro
May 28, 2021·JHEP Reports : Innovation in Hepatology·Maria ButiZobair Younossi
Jul 31, 2021·World Journal of Gastroenterology : WJG·María B PisanoPamela Valva
Nov 19, 2020·Cell Reports Medicine·Christine Y L ThamAntonio Bertoletti

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