Targeting histone deacetylases for the treatment of Huntington's disease.

CNS Neuroscience & Therapeutics
Steven G Gray

Abstract

Huntington's disease is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite the identification of the causative element, an expanded toxic polyglutamine tract in the mutant Huntingtin protein, treatment options for patients with this disease remain limited. In the following review I assess the current evidence suggesting that a family of important regulatory proteins known as histone deacetylases may be an important therapeutic target in the treatment of this disease.

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Citations

Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Badi Sri SailajaEran Meshorer
Nov 15, 2011·Clinical and Experimental Pharmacology & Physiology·Meijuan ZhangYun Xu
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Oct 4, 2018·Frontiers in Genetics·Evangelia TzikaAxel Imhof

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