Targeting histone demethylases in cancer therapy.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Steven Grant

Abstract

A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents.

References

Jan 1, 1985·Advances in Enzyme Regulation·A CihákJ Skoda
May 18, 2001·Nature·J Taipale, P A Beachy
Aug 11, 2001·Science·T Jenuwein, C D Allis
Jan 16, 2007·Molecular Cell·Yang Shi, Johnathan R Whetstine
Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Mar 8, 2007·Nature Reviews. Molecular Cell Biology·Robert J Klose, Yi Zhang
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yi HuangRobert A Casero

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Citations

Dec 15, 2010·The Journal of Biological Chemistry·Young Sun JeongYong-Kook Kang
Oct 6, 2010·Antioxidants & Redox Signaling·Anthony R Cyr, Frederick E Domann
May 4, 2011·Current Opinion in Pulmonary Medicine·Isaac K SundarIrfan Rahman
Jun 23, 2011·Molecular Cancer Research : MCR·Omar Y MianGordon D Ginder
Oct 22, 2014·ACS Chemical Biology·Laura J MarholzXiang Wang
Sep 24, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yufeng HuangWangkun Lu
Feb 28, 2015·Neuroepigenetics·John S SatterleeAmy C Lossie
Aug 3, 2010·Cell Cycle·Steven Grant
Aug 3, 2010·Cell Cycle·Jesús Pérez-Losada, Isidro Sanchez-Garcia
Jul 18, 2017·Molecular Medicine Reports·Tongfu FengYuanzhen Zhang
Sep 1, 2016·Neuro-oncology Practice·Benjamin Purow

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