Targeting HIV services to male migrant workers in southern Africa would not reverse generalized HIV epidemics in their home communities: a mathematical modeling analysis

International Health
Daniel J KleinAnna Bershteyn

Abstract

Migrant populations such as mine workers contributed to the spread of HIV in sub-Saharan Africa. We used a mathematical model to estimate the community-wide impact of targeting treatment and prevention to male migrants. We augmented an individual-based network model, EMOD-HIV v0.8, to include an age-dependent propensity for males to migrate. Migrants were exposed to HIV outside their home community, but continued to participate in HIV transmission in the community during periodic visits. Migrant-targeted interventions would have been transformative in the 1980s to 1990s, but post-2015 impacts were more modest. When targetable migrants comprised 2% of adult males, workplace HIV prevention averted 3.5% of community-wide infections over 20 years. Targeted treatment averted 8.5% of all-cause deaths among migrants. When migrants comprised 10% of males, workplace prevention averted 16.2% of infections in the community, one-quarter of which were among migrants. Workplace prevention and treatment acted synergistically, averting 17.1% of community infections and 11.6% of deaths among migrants. These estimates do not include prevention of secondary spread of HIV or tuberculosis at the workplace. Though cost-effective, targeting migrants ...Continue Reading

References

Jan 27, 2007·AIDS·Megan CoffeeGeoff P Garnett
Jul 1, 2009·American Journal of Industrial Medicine·David ReesPam Sonnenberg
Jun 12, 2010·Lancet·Deborah DonnellUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Jul 17, 2010·PloS One·Carol S CamlinRachel C Snow
Mar 2, 2011·AIDS·Miles Q OttMarie-Louise Newell
Mar 2, 2011·Global Public Health·Joanna Vearey
Jun 21, 2011·Sexually Transmitted Infections·Leigh F Johnson, Peter J White
Jan 14, 2012·The Journal of Infectious Diseases·Ronald H Gray, Maria J Wawer
Jan 14, 2012·The Journal of Infectious Diseases·James P HughesUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Sep 28, 2012·AIDS·Gesine Meyer-RathSydney Rosen
Dec 29, 2012·Sexually Transmitted Infections·Sevgi O Aral, Willard Cates
Aug 30, 2013·Journal of the Royal Society, Interface·Anna BershteynPhilip A Eckhoff
Dec 21, 2013·Current Opinion in HIV and AIDS·Frank TanserTill Bärnighausen
Jan 24, 2014·The New England Journal of Medicine·Gavin J ChurchyardUNKNOWN Thibela TB Study Team
Apr 25, 2014·The New England Journal of Medicine·Gavin J ChurchyardAlison D Grant

❮ Previous
Next ❯

Citations

Mar 4, 2015·International Health·Philip A Eckhoff, Andrew J Tatem
Jan 11, 2018·Nature Communications·Ameya R KirtaneGiovanni Traverso
Jul 10, 2018·Pathogens and Disease·Anna BershteynUNKNOWN Institute for Disease Modeling
Feb 5, 2019·Pathogens and Disease·Cliff C Kerr
May 12, 2020·PLoS Computational Biology·C Marijn HazelbagWim Delva
Mar 27, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Britta L JewellAnna Bershteyn

❮ Previous
Next ❯

Methods Mentioned

BETA
circumcision

Software Mentioned

HIV
EMOD

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of STD & AIDS
Maurice I MiddlebergPeter Twyman
International Journal of STD & AIDS
R M D Zebaze
International Journal of STD & AIDS
P E Peters
© 2022 Meta ULC. All rights reserved