Targeting HMGB1 in inflammation.

Biochimica Et Biophysica Acta
Huan Yang, Kevin J Tracey

Abstract

High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and targeting HMGB1 with antibodies or specific antagonists is protective in established preclinical inflammatory disease models including lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury. Future advances in this field will stem from understanding the biological basis for the success of targeting HMGB1 to therapeutic improvement in the treatment of inflammation, infection and ischemia-reperfusion induced injury.

Citations

Aug 28, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Ryszard SmolarczykStanisław Szala
Sep 17, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dong-Chan KimJong-Sup Bae
Feb 23, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kazuki MurakamiTeruaki Imada
Mar 7, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Li XuXiaoliang Wang
May 26, 2011·Basic Research in Cardiology·Wim MartinetGuido R Y De Meyer
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Feb 15, 2014·Advances in Wound Care·Cordelia ZiraldoYoram Vodovotz
Dec 15, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E KirkmanG Cooper
Nov 3, 2010·Journal of Neuroinflammation·An-Gaëlle CeulemansYvette Michotte
Feb 22, 2012·Arthritis Research & Therapy·Agneta ZickertIva Gunnarsson
Nov 4, 2010·Critical Care : the Official Journal of the Critical Care Forum·Valeria ManganelliGiovanna Delogu
Nov 9, 2012·Journal of Leukocyte Biology·Monowar AzizPing Wang
Apr 14, 2010·Molecular Medicine·Hanna SchierbeckHelena Erlandsson Harris
Nov 17, 2012·World Journal of Gastroenterology : WJG·Lu-Wen WangZuo-Jiong Gong
Dec 3, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hayoung YooJong-Sup Bae
Jan 29, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sae-Kwang KuJong-Sup Bae
Feb 4, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Tomasz CichońStanisław Szala
Sep 23, 2014·BioMed Research International·Carla TripiscianoViktoria Weber
Oct 13, 2014·Nature Chemical Biology·Sanghee LeeSeung Bum Park
Nov 22, 2013·Epidemiology·Serena FossatiJoel Schwartz
Apr 12, 2011·Clinical Reviews in Bone and Mineral Metabolism·Joseph P Bidwell, Fredrick M Pavalko
Mar 29, 2011·The Journal of Veterinary Medical Science·Taku MiyashoHiroshi Yokota
Nov 16, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sabina Walker, Peter D Drummond
Mar 9, 2012·Expert Review of Anti-infective Therapy·Evangelos J Giamarellos-Bourboulis, Maria Raftogiannis
Aug 13, 2013·Journal of the American Academy of Dermatology·Young LeeJeung-Hoon Lee
Dec 31, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anna BangertZiya Kaya
Jan 29, 2013·Toxicology and Applied Pharmacology·Wonhwa LeeJong-Sup Bae
Nov 3, 2012·Trends in Immunology·Hideyuki YanaiTadatsugu Taniguchi
Nov 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wonhwa LeeJong-Sup Bae
Jan 15, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xu Dong ZhaoXiao Jie Lu
Mar 26, 2011·The Journal of Surgical Research·Hong-guang Bao, Sha Li
Jun 24, 2010·Clinics in Perinatology·Irina A Buhimschi, Catalin S Buhimschi

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