Abstract
The inhibitory kappa B kinases (IKKs) and IKK related kinases are crucial regulators of the pro-inflammatory transcription factor, nuclear factor kappa B (NF-κB). The dysregulation in the activities of these kinases has been reported in several cancer types. These kinases are known to regulate survival, proliferation, invasion, angiogenesis, and metastasis of cancer cells. Thus, IKK and IKK related kinases have emerged as an attractive target for the development of cancer therapeutics. Several IKK inhibitors have been developed, few of which have advanced to the clinic. These inhibitors target IKK either directly or indirectly by modulating the activities of other signaling molecules. Some inhibitors suppress IKK activity by disrupting the protein-protein interaction in the IKK complex. The inhibition of IKK has also been shown to enhance the efficacy of conventional chemotherapeutic agents. Because IKK and NF-κB are the key components of innate immunity, suppressing IKK is associated with the risk of immune suppression. Furthermore, IKK inhibitors may hit other signaling molecules and thus may produce off-target effects. Recent studies suggest that multiple cytoplasmic and nuclear proteins distinct from NF-κB and inhibitory κB...Continue Reading
Citations
Jan 1, 2019·Journal of Pineal Research·Tian LiYang Yang
May 15, 2020·PloS One·Hope MurphyHana M Dobrovolny
May 8, 2020·International Journal of Oncology·Zequn LiPenghong Song
Nov 14, 2019·Cancers·Serena Di CosimoMatteo Dugo
Nov 11, 2018·Cancers·Justyna Struzik, Lidia Szulc-Dąbrowska
Nov 27, 2018·Cancer Cell International·Xiaojun ZhouFeng Guo
Aug 1, 2018·Biomedicines·Yu Rou PuarVinay Tergaonkar
Oct 23, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Subash C GuptaKishore B Challagundla
Nov 18, 2020·Biomolecules·Andrea Baier, Ryszard Szyszka
Feb 3, 2021·Antioxidants·Peter F SuraiMichael T Kidd
Mar 21, 2021·Journal of Food Biochemistry·Linjiang SongXin Liang
May 1, 2021·Nature Cancer·Christine S MoonAdolfo A Ferrando
May 24, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Anusmita Shekher Puneet
Jun 17, 2021·Acta Biochimica Et Biophysica Sinica·Tingting HuangHua Tian
Jul 8, 2021·Molecules and Cells·An SongXiaomeng Song
Sep 20, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Xueqiang PengHangyu Li