Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

Expert Opinion on Therapeutic Targets
Victor FattoriWaldiceu A Verri

Abstract

IL-33 signals through ST2 receptor and promotes inflammation by activating downstream pathways culminating in the production of pro-inflammatory mediators such as IL-1β, TNF-α, and IL-6 in an NF-κB-dependent manner. In fact, compelling evidence has demonstrated the importance of IL-33/ST2 in both innate and adaptive immune responses in diseases presenting pain as an important clinical symptom. Areas covered: IL-33 is a pleiotropic cytokine with varied immune functions. Dysregulation of this pathway has been described as a key step in varied immune responses. Further, IL-33 contributes to peripheral and spinal cord nociceptor neuron sensitization in innate and adaptive inflammatory immune responses as well as in neuropathic and cancer pain. In this sense, targeting IL-33/ST2 signaling is a promising therapeutic approach. Expert opinion: The modulation of IL-33/ST2 signaling represents a possible approach in regulating immune functions. In addition to immune function, strategies targeting IL-33/ST2 signaling pathway display a favorable preclinical analgesic profile in both acute and chronic models of pain. Therefore, IL-33-targeting therapies represent a potential target for the development of novel analgesic drugs given that IL-...Continue Reading

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Citations

Sep 5, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Victor FattoriWaldiceu A Verri
Feb 16, 2019·Hepatology Communications·Nataliya RazumilavaJuanita L Merchant
Jul 10, 2019·Oxidative Medicine and Cellular Longevity·Kun-Lin ChenGen-Lin Wang
Nov 19, 2019·Mediators of Inflammation·Serafinella Patrizia CannavòSebastiano Gangemi
Feb 13, 2020·Frontiers in Immunology·Gilson Gonçalves Dos SantosMaripat Corr
Jun 6, 2018·Frontiers in Immunology·Larissa Staurengo-FerrariWaldiceu A Verri
Nov 20, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Victor FattoriWaldiceu A Verri
Nov 29, 2020·Immunology Letters·Victor FattoriWaldiceu A Verri
Apr 1, 2021·Journal of Neuroinflammation·Ruixiang ChenBoyi Liu

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