Sep 27, 2019

Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders

CNS Drugs
Niels BergslandRobert Zivadinov

Abstract

While iron has an important role in the normal functioning of the brain owing to its involvement in several physiological processes, dyshomeostasis has been found in many neurodegenerative disorders, as evidenced by both histopathological and imaging studies. Although the exact causes have remained elusive, the fact that altered iron levels have been found in disparate diseases suggests that iron may contribute to their development and/or progression. As such, the processes involved in iron dyshomeostasis may represent novel therapeutic targets. There are, however, many questions about the exact interplay between neurodegeneration and altered iron homeostasis. Some insight can be gained by considering the parallels with respect to what occurs in healthy aging, which is also characterized by increased iron throughout many regions in the brain along with progressive neurodegeneration. Nevertheless, the exact mechanisms of iron-mediated damage are likely disease specific to a certain degree, given that iron plays a crucial role in many disparate biological processes, which are not always affected in the same way across different neurodegenerative disorders. Moreover, it is not even entirely clear yet whether iron actually has a ca...Continue Reading

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Mentioned in this Paper

Imaging Studies
Study
In Vivo
Iron Metabolism Disorders
Brain
Nerve Degeneration
Iron Ion Homeostasis
Pharmacologic Substance
Neuroimaging
Aging

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