PMID: 16515530Mar 7, 2006Paper

Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors

Current Drug Targets
Alexei VassilevF M Uckun

Abstract

Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), have been identified as potential drug targets to treat diverse diseases including cancer and disorders of the immune system. Here we review advances in JAK3 and BTK inhibitors and describe the therapeutic potential of these potent agents in the clinical setting.

Citations

Jun 24, 2008·Purinergic Signalling·Shripad S Bhagwat
Jan 1, 2008·Expert Review of Clinical Immunology·Bozena Kaminska, Karolina Swiatek-Machado
Feb 27, 2008·International Reviews of Immunology·Fatih M Uckun
Feb 1, 2007·The Journal of Biological Chemistry·Marie DinhJ Michael Bradshaw

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