Targeting kinases in Plasmodium and Schistosoma: Same goals, different challenges

Biochimica Et Biophysica Acta
Christian Doerig, C G Grevelding

Abstract

With respect to parasite-induced infectious diseases of worldwide importance, members of the genera Plasmodium and Schistosoma are top pathogens. Nearly half a billion people suffer from malaria caused by Plasmodium spp. and schistosomiasis (bilharzia) induced by Schistosoma spp. Resistance against essentially all drugs used for malaria treatment has been reported. For schistosomiasis justified fear of upcoming resistance is discussed against the background of only one widely used drug for treatment. Research of the recent decade has demonstrated that essential steps of the biology of these and other parasites are controlled by kinases, which represent attractive targets for new-generation antiparasitic compounds. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases.

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Citations

Aug 13, 2015·Parasites & Vectors·Noemi Cowan, Jennifer Keiser
May 10, 2016·Future Microbiology·Jamal Khalife, Christine Pierrot
Feb 16, 2019·Biomolecules·Maria João GouveiaNuno Vale
Apr 22, 2018·Journal of Proteome Research·Brittany N PeaseDebopam Chakrabarti

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