PMID: 25732792Mar 4, 2015Paper

Targeting Krüppel-like factor 5 (KLF5) for cancer therapy

Current Topics in Medicinal Chemistry
Yu GaoJia Zhou

Abstract

Krüppel-like factor 5 (KLF5) belongs to a family of zinc-finger-containing transcription factors which are involved in regulating expression of a wide range of genes, thereby affecting diverse cellular functions. The activities of KLF5 are regulated by multiple signaling pathways including Wnt, Ras, TGFβ, Hippo, Notch, retinoid acid receptor, and hormone receptors. The expression of KLF5 is frequently abnormal in human cancers and the functions of KLF5 are context dependent. Accumulating evidence suggests that KLF5 represents a novel therapeutic target for cancer therapy. In this review, we discuss the potential biological functions of KLF5 associated with several key signaling pathways that are relevant to cancer as well as the involvement of KLF5 in various human cancers. We also describe the progress in the discovery and development of small molecules targeting KLF5 as potential therapeutics that may benefit cancer patients. The challenges and future research directions on the drug discovery of KLF5 ligands are also presented.

Citations

Oct 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dexiang ZhangHoubao Liu
Jun 28, 2016·European Journal of Medicinal Chemistry·Ye DingJia Zhou
Jul 10, 2019·International Journal of Cancer. Journal International Du Cancer·Ying ZhouKaikai Shen
Oct 19, 2019·The Journal of Biological Chemistry·Yingying WuCeshi Chen
May 30, 2020·International Journal of Molecular Sciences·Jochen RutzBorna Relja
Aug 17, 2018·Experimental and Therapeutic Medicine·Yanlan OuyangSainan Qiu
Dec 1, 2020·Journal of Experimental & Clinical Cancer Research : CR·Marta De DonatoDaniela Gallo
Oct 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gyun-Sik OhSeung-Whan Kim
Jan 13, 2021·Cancers·Poyil PratheeshkumarKhawla S Al-Kuraya
Apr 4, 2021·Cancer Science·Yao Luo, Ceshi Chen
Sep 13, 2020·Pathology, Research and Practice·Cunjin NanYinghe Chen
Aug 3, 2021·BioMed Research International·Qiang SunXiaofeng Zhu
Aug 10, 2021·Gastroenterology Research and Practice·Jun-Chen LiHao Zhang
Nov 16, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lei YangJiao Liu
Dec 22, 2021·DNA and Cell Biology·Shuo YangHong Li

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