Targeting Leukemia Stem Cells in the Bone Marrow Niche

Biomedicines
Sarah K TasianSergio Rutella

Abstract

Abst ract: The bone marrow (BM) niche encompasses multiple cells of mesenchymal and hematopoietic origin and represents a unique microenvironment that is poised to maintain hematopoietic stem cells. In addition to its role as a primary lymphoid organ through the support of lymphoid development, the BM hosts various mature lymphoid cell types, including naïve T cells, memory T cells and plasma cells, as well as mature myeloid elements such as monocyte/macrophages and neutrophils, all of which are crucially important to control leukemia initiation and progression. The BM niche provides an attractive milieu for tumor cell colonization given its ability to provide signals which accelerate tumor cell proliferation and facilitate tumor cell survival. Cancer stem cells (CSCs) share phenotypic and functional features with normal counterparts from the tissue of origin of the tumor and can self-renew, differentiate and initiate tumor formation. CSCs possess a distinct immunological profile compared with the bulk population of tumor cells and have evolved complex strategies to suppress immune responses through multiple mechanisms, including the release of soluble factors and the over-expression of molecules implicated in cancer immune eva...Continue Reading

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Citations

Aug 1, 2019·Stem Cells and Development·Lacey Brennan, Aru Narendran
Jan 8, 2021·International Journal of Laboratory Hematology·Juan LiJingchun Jin

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Methods Mentioned

BETA
MDS
chromosomal aberrations
xenografts
xenograft

Clinical Trials Mentioned

NCT02835729
NCT02404480
NCT02270463
NCT02113982
NCT02848248
NCT02742727
NCT01766375
NCT02678338
NCT02367196
NCT02817633

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