Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

British Journal of Cancer
R G MorganA C Williams

Abstract

Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49) potentiates canonical Wnt/β-catenin signalling and is a marker of normal stem cells in several tissues, including the intestine. Consistent with stem cell potential, single isolated LGR5+ cells from the gut generate self-organising crypt/villus structures in vitro termed organoids or 'mini-guts', which accurately model the parent tissue. The well characterised deregulation of Wnt/β-catenin signalling that occurs during the adenoma-carcinoma sequence in colorectal cancer (CRC) renders LGR5 an interesting therapeutic target. Furthermore, recent studies demonstrating that CRC tumours contain LGR5+ subsets and retain a degree of normal tissue architecture has heightened translational interest. Such reports fuel hope that specific subpopulations or molecules within a tumour may be therapeutically targeted to prevent relapse and induce long-term remissions. Despite these observations, many studies within this field have produced conflicting and confusing results with no clear consensus on the therapeutic value of LGR5. This review will recap the various oncogenic and tumour suppressive roles that have been described for the LGR5 molecule in CRC. It will further...Continue Reading

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Citations

Feb 23, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Yongning JiaJiafu Ji
Oct 15, 2019·Oncotarget·Balaji KrishnamacharyShrikant Anant
Jan 3, 2020·International Journal of Molecular Medicine·Masuko Katoh, Masaru Katoh
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Methods Mentioned

BETA
nuclear translocation
xenografting
PCR
transfection
xenograft
xenografts

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