Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer

Cancer Letters
Qiuping LiuGuanbin Song

Abstract

One of the most important metabolic hallmarks of cancer cells is deregulation of lipid metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake and lipolysis have also been considered as means of FA acquisition in cancer cells. FAs are involved in various aspects of tumourigenesis and tumour progression. Therefore, targeting lipid metabolism is a promising therapeutic strategy for human cancer. Recent studies have shown that reprogramming lipid metabolism plays important roles in providing energy, macromolecules for membrane synthesis, and lipid signals during cancer progression. Moreover, accumulation of lipid droplets in cancer cells acts as a pivotal adaptive response to harmful conditions. Here, we provide a brief review of the crucial roles of FA metabolism in cancer development, and place emphasis on FA origin, utilization and storage in cancer cells. Understanding the regulation of lipid metabolism in cancer cells has important implications for exploring a new therapeutic strategy for management and treatment of cancer.

References

Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·M S NeshatC L Sawyers
Nov 21, 2002·Experimental Cell Research·Victor E NavaSarah Spiegel
Jan 30, 2003·Clinical Biochemistry·K KolanjiappanS Manoharan
Dec 23, 2003·Journal of Cellular Biochemistry·Antonella BaronMassimo Loda
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Johannes V SwinnenGuido Verhoeven
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Martin H HagerMichael R Freeman
Sep 9, 2006·Journal of Lipid Research·Nica M BorradaileJean E Schaffer
Oct 18, 2006·International Journal of Cancer. Journal International Du Cancer·Majida Esslimani-SahlaHenri Rochefort
Jan 16, 2007·Journal of Pharmacological Sciences·Aya IharaAtsushi Nakajima
Mar 29, 2007·The Journal of Physical Chemistry. B·Samuli OllilaIlpo Vattulainen
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Dec 7, 2007·Digestive Diseases and Sciences·Lynn W MainesCharles D Smith
Dec 18, 2007·Cell Death and Differentiation·S Lucken-ArdjomandeJ-C Martinou
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Matthias P Wymann, Roger Schneiter
Jul 23, 2008·Molecular Cancer Therapeutics·Dimitri PchejetskiOlivier Cuvillier
Dec 17, 2008·Cancer Research·Gianluca SalaMarco Falasca
Dec 25, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ayman E M MahdyXiang Liu
Apr 1, 2007·Future Lipidology·Maryam AhmadianHei Sook Sul
Aug 20, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sung-Won ShinJoo-In Park
Dec 1, 2009·Cell·Robert V Farese, Tobias C Walther
Dec 30, 2009·The Journal of Clinical Investigation·Ismael SamudioMichael Andreeff
Feb 16, 2010·Cancer Chemotherapy and Pharmacology·James W AntoonBarbara S Beckman
Mar 9, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Patricia T Bozza, João P B Viola
May 22, 2010·The Journal of Biological Chemistry·Hiroyuki AriyamaHiroyuki Arai
Dec 17, 2010·Current Cancer Drug Targets·M MontopoliL Caparrotta
Feb 2, 2011·Molecular Cancer Therapeutics·Nancy B KuemmerleWilliam B Kinlaw
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Aug 3, 2011·Journal of Cell Science·Chithra N KeembiyehettyJohn A Hanover
Aug 19, 2011·Molecular Systems Biology·Daniela GaglioFerdinando Chiaradonna
Nov 1, 2011·Nature Medicine·Kristin M NiemanErnst Lengyel
Nov 18, 2011·The Journal of Biological Chemistry·Dawn L Brasaemle, Nathan E Wolins

❮ Previous
Next ❯

Citations

Jun 8, 2018·The International Journal of Biological Markers·Brian I CarrFranco Trevisani
Apr 22, 2018·Journal of Lipid Research·Ikrame LazarLaurence Nieto
Jun 27, 2019·Fundamental & Clinical Pharmacology·Lixia JiGuo-Hui Jiang
Jun 17, 2020·Journal of Cellular and Molecular Medicine·Lumin ChenWei-Chun Chang
Jul 18, 2020·Cells·Jung-Ae Kim
May 1, 2018·Current Medicinal Chemistry·Camille AttanéCatherine Muller
Oct 27, 2018·Pharmaceuticals·Stephanie RockfieldMeera Nanjundan
Dec 20, 2018·Biosensors·Svitlana M Levchenko, Junle Qu
Feb 23, 2019·Journal of Cellular Physiology·Wei HuLuanhai Ou
Jul 24, 2020·Pharmacological Reports : PR·Tanweer HaiderVandana Soni
Jun 3, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ziyu HanJie Tian
Aug 6, 2019·Pharmacological Reports : PR·Oksana Maksymchuk, Vladimir Kashuba
Sep 3, 2019·Journal of Cellular and Molecular Medicine·Fan WuTao Jiang
Mar 12, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jin-Yu HuangHui-Mian Xu
Jan 9, 2019·Frontiers in Cell and Developmental Biology·Je Lin SieowSiew Cheng Wong
Jun 13, 2020·International Journal of Molecular Sciences·Bianka BojkováMagdalena Wszedybyl-Winklewska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Nature Reviews. Cancer
Florian Röhrig, Almut Schulze
Acta Biochimica Et Biophysica Sinica
De HuangHuafeng Zhang
© 2022 Meta ULC. All rights reserved