Targeting liver X receptors in cancer therapeutics

Nature Reviews. Cancer
Chin-Yo Lin, Jan-Åke Gustafsson

Abstract

Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses. There is now accumulating evidence to support the involvement of LXRs in a variety of malignancies and the potential efficacy of their ligands in these diseases. This Review summarizes the discovery and characterization of LXRs and their ligands, their effects and mechanisms in preclinical cancer models, and the future directions of basic and translational LXR research in cancer therapeutics.

References

May 1, 1995·Genes & Development·P J WillyD J Mangelsdorf
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·M TeboulJ A Gustafsson
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C SongS Liao
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·B A JanowskiD J Mangelsdorf
Apr 29, 1999·Cell·UNKNOWN Nuclear Receptors Nomenclature Committee
Nov 23, 2000·Genes & Development·J R SchultzB Shan
May 3, 2002·Journal of Medicinal Chemistry·Jon L CollinsTimothy M Willson
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sean B JosephPeter Tontonoz
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ling WangJan-Ake Gustafsson
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco J EstevaGeorge D Demetri
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bryan A LaffittePeter Tontonoz
Jul 9, 2003·The Journal of Biological Chemistry·Emi KanekoMakoto Makishima
Feb 20, 2004·Journal of Mammary Gland Biology and Neoplasia·S Ali, R C Coombes
Aug 5, 2004·Journal of Lipid Research·Elaine M QuinetPonnal Nambi
Aug 24, 2004·Current Cancer Drug Targets·Z CuligA Hobisch
Oct 7, 2004·Molecular Genetics and Metabolism·Keith A HouckThomas P Burris
Nov 3, 2004·Nature Reviews. Drug Discovery·Hinrich GronemeyerVincent Laudet
Nov 24, 2004·The Journal of Biological Chemistry·Radosveta P KoldamovaJohn S Lazo
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Annabel F ValledorChristopher K Glass
Apr 16, 2005·The Journal of Biological Chemistry·Isabelle GerinOrmond A MacDougald
Sep 10, 2005·Journal of Lipid Research·Jogchum PlatRonald P Mensink
Feb 18, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Daniel WalcherNikolaus Marx
Mar 3, 2006·The Journal of Clinical Investigation·Noam Zelcer, Peter Tontonoz
Jul 1, 1932·The Journal of Clinical Investigation·M Yasuda, W R Bloor
Sep 7, 2006·Journal of Neuroscience Research·Claudia HindingerStephen A Stohlman
Oct 3, 2006·Nature Genetics·Jason S CarrollMyles Brown
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Konstantin H DragnevEthan Dmitrovsky
Apr 10, 2007·Biochemical and Biophysical Research Communications·Chih-Pin ChuuShutsung Liao
Jun 5, 2007·PLoS Genetics·Chin-Yo LinEdison T Liu
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Noam ZelcerPeter Tontonoz
Sep 4, 2007·The Journal of Biological Chemistry·Mark A BirrellMaria G Belvisi

❮ Previous
Next ❯

Citations

Dec 5, 2017·Nature Communications·Gregory SegalaSandrine Silvente-Poirot
Mar 25, 2018·Molecular Carcinogenesis·Qiang WangXiaoli Ju
Jun 5, 2019·Nanomaterials·Elena Sánchez-LópezEliana B Souto
May 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Teresa BilottaMarco Cippitelli
Jun 19, 2020·Cancers·Lorey K SmithKaren E Sheppard
Mar 10, 2016·Current Opinion in Lipidology·Sonja C StadlerRalph Burkhardt
Jun 5, 2020·Endocrinology·Maud VoisinMichael J Garabedian
Jul 17, 2020·British Journal of Pharmacology·Lorenzo Pontini, Maura Marinozzi
Apr 20, 2016·Frontiers in Genetics·Darius WlochowitzMehmet Gültas
May 7, 2016·Journal of Molecular Endocrinology·Ylenia Perone, Luca Magnani
Sep 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Matias SonciniVincenzo Russo
Sep 21, 2016·Endocrine-related Cancer·Damien A LeachCharlotte L Bevan
Jun 8, 2018·Current Medicinal Chemistry·Francisco Blanco-VacaJosep Julve
Oct 25, 2016·Nature Reviews. Cancer·Peter J MullenLinda Z Penn
Jul 23, 2020·Nature Metabolism·Binlu HuangChenqi Xu
May 20, 2019·Journal of Cellular Biochemistry·Xiaolong LiangZheng Xiang
Oct 21, 2020·British Journal of Pharmacology·Julio BuñayJean-Marc A Lobaccaro
Aug 19, 2018·Cancer Research·Sandrine Silvente-PoirotMarc Poirot
Jul 1, 2020·The Journal of Investigative Dermatology·Ping WangAie Xu
Dec 10, 2019·Cell Metabolism·Marteinn Thor SnaebjornssonAlmut Schulze
Oct 13, 2019·Seminars in Cancer Biology·Michela PaselloKatia Scotlandi
Nov 24, 2020·Frontiers in Immunology·Maria Teresa BilottaMarco Cippitelli
Dec 23, 2020·International Journal of Molecular Sciences·Shivangi SrivastavaChin-Yo Lin
Oct 25, 2020·Trends in Pharmacological Sciences·Zdeněk DvořákSridhar Mani
Mar 6, 2021·Life Sciences·Qiang WangHeng Zhang
Feb 20, 2021·Frontiers in Oncology·Tiffany ScullyEmily Jane Gallagher
Feb 19, 2021·The Journal of Experimental Medicine·Xueli BianZhimin Lu
Apr 29, 2020·Pharmacology & Therapeutics·Yun ZhaoXin Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.