Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of β-catenin

Journal of Cancer
Zhi-Chang ZhangXiao-Lin Li

Abstract

Osteosarcoma (OS), which affects adolescents especially during a growth spurt, has the highest incidence of any primary malignant bone tumour, and a high rate of early metastasis leading to a very poor prognosis. In recent years, non-coding RNAs, especially long non-coding RNAs (lncRNAs) have attracted more and more attention as novel epigenetic regulators in a variety of tumours, including OS. Most recently, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was found to play an important role in OS progression by modulating the enhancers of zeste homolog 2 (EZH2). Furthermore, MALAT1 could inhibit the expression of E-cadherin and promote the expression of β-catenin, and this phenomenon might be the outcome of MALAT1-induced EZH2 activation. In this study, we investigated the vital function of MALAT1 in the progression of OS and its potential leading mechanism, altering the expression and localization of β-catenin via epigenetic transcriptional regulation by interacting with EZH2. With the help of MALAT1 silencing using small interfering RNAs (siRNAs), the loss of E-cadherin of MNNG/HOS cells was rescued, and the abnormal expression and localization of β-catenin were corrected at the same time. Overall, our resear...Continue Reading

Citations

Aug 7, 2018·Investigational New Drugs·Chongchong WangLi Cheng
Aug 15, 2019·Journal of Cellular and Molecular Medicine·Meiqin ZhangJin Zhang
Mar 16, 2019·Lipids in Health and Disease·Hongrong LiYiling Wu
May 10, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yuqian HuLijuan Lin
Nov 9, 2020·Journal of Translational Medicine·Jianguo LaiNing Liao
Mar 2, 2021·Acta Pharmaceutica Sinica. B·Yuanyuan ChenSen Zhang
Feb 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kai SuShiyin Ma
May 1, 2021·International Journal of Molecular Sciences·Cinzia AuriliaMaria Luisa Brandi
Apr 11, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jingyi LiuJunping Zhang

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Methods Mentioned

BETA
transfection
PCR
electrophoresis
flow cytometry
oncotherapy
surgical resection
ubiquitination

Software Mentioned

ARRIVE
RStudio

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