Targeting Low Disease Activity in Elderly-Onset Rheumatoid Arthritis: Current and Future Roles of Biological Disease-Modifying Antirheumatic Drugs

Drugs & Aging
Takahiko Sugihara, Masayoshi Harigai

Abstract

Elderly rheumatoid arthritis (RA) is classified into two clinical subsets, elderly-onset RA (EORA) and younger-onset elderly RA. With the improvement of life expectancy in the general population and advent of the super-aging society, the number of patients with EORA is anticipated to increase. Both large and small joints are affected initially at onset, and individuals with early EORA have higher scores of disease activity and levels of acute-phase reactants than those with early younger-onset RA. EORA is a progressive disease similar to younger-onset RA. Tumor necrosis factor (TNF) inhibitors are equally or slightly less effective in elderly patients than in younger patients with RA, and disease duration may have a greater impact on disease outcomes than age. Evidence of non-TNF biological disease-modifying antirheumatic drug use in EORA is limited. TNF inhibitors may not increase the risk for infection in elderly patients any more than methotrexate; however, increasing age is an independent and strong risk factor for serious infections in patients with RA. Treatment choice in patients with EORA is strongly influenced by comorbidities, especially cardiovascular disease, chronic lung disease, and frailty. To prevent progression...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A B NewmanUNKNOWN Cardiovascular Health Study Research Group
Nov 15, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·C Gómez-VaqueroD Roig-Escofet
Mar 29, 2002·Arthritis and Rheumatism·Michele F DoranSherine E Gabriel
Oct 2, 2002·Arthritis and Rheumatism·Michele F DoranSherine E Gabriel
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael G ShlipakAnne B Newman
Feb 12, 2005·Rheumatology·H Chevillotte-MaillardJ F Maillefert
Mar 8, 2005·Arthritis and Rheumatism·Hilal Maradit-KremersSherine E Gabriel
Sep 10, 2005·Annals of the Rheumatic Diseases·R FleischmannP Peloso
Jan 18, 2006·Annals of the Rheumatic Diseases·Z TutuncuA Kavanaugh
Mar 2, 2006·Arthritis and Rheumatism·Josef S SmolenUNKNOWN Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) S
Aug 16, 2006·Rheumatology·A YoungUNKNOWN Early Rheumatoid Arthritis Study (ERAS) group
Mar 21, 2007·Annals of Internal Medicine·Yvonne P M Goekoop-RuitermanBen A C Dijkmans
May 2, 2007·Arthritis and Rheumatism·Stéphane GenevayUNKNOWN Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis
Aug 1, 2007·Arthritis and Rheumatism·Gabriela SchmajukDaniel H Solomon
Nov 6, 2007·The New England Journal of Medicine·Masayoshi HarigaiUNKNOWN Pneumocystis Pneumonia under Anti-Tumor Necrosis Factor Therapy (PAT) Study Group
Jan 9, 2008·The American Journal of Geriatric Pharmacotherapy·Emily R HajjarJoseph T Hanlon
Nov 19, 2008·Annals of the Rheumatic Diseases·B J RadovitsR F J M Laan
May 30, 2009·Rheumatology·Beáta J RadovitsRoland F J M Laan
Jun 10, 2009·International Journal of Immunopathology and Pharmacology·A MiglioreA Galluccio
Jun 24, 2009·Clinical Reviews in Allergy & Immunology·Matteo FilippiniRoberto Gorla
Aug 5, 2009·Rheumatology·Yi-Ming ChenDer-Yuan Chen
Feb 27, 2010·Arthritis and Rheumatism·Paul EmeryUNKNOWN Combination of Methotrexate and Etanercept in Early Rheumatoid Arthritis Trial Group
Mar 2, 2010·Arthritis and Rheumatism·Elena MyasoedovaSherine E Gabriel
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee

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Citations

Jan 25, 2017·Journal of Pharmaceutical Health Care and Sciences·Morihiro OkadaYoshimichi Sai
May 15, 2020·The Tohoku Journal of Experimental Medicine·Naoki KondoNaoto Endo
Jan 5, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Tsuyoshi Takeda
Sep 15, 2017·Clinical Rheumatology·Herwig PieringerLorenz Auer-Hackenberg
Jun 12, 2021·Zeitschrift für Gerontologie und Geriatrie·Ilke Coskun Benlidayi, Yesim Gokce Kutsal

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