Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

Trends in Molecular Medicine
Annelies DemeyerRudi Beyaert

Abstract

MALT1 is a signaling protein that plays a key role in immunity, inflammation, and lymphoid malignancies. For a long time MALT1 was believed to function as a scaffold protein, providing an assembly platform for other signaling proteins. This view changed dramatically when MALT1 was also found to have proteolytic activity and a capacity to fine-tune immune responses. Preclinical studies have fostered the belief that MALT1 is a promising therapeutic target in autoimmunity and B cell lymphomas. However, recent studies have shown that mice expressing catalytically-inactive MALT1 develop multi-organ inflammation and autoimmunity, and thus have tempered this initial enthusiasm. We discuss recent findings, highlighting the urgent need for a better mechanistic and functional understanding of MALT1 in host defense and disease.

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Citations

Jun 1, 2017·Biomedicines·Véronique Imbert, Jean-François Peyron
Jul 20, 2017·Nature Immunology·Inna S AfoninaRudi Beyaert
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Apr 29, 2020·EMBO Reports·Elien Van NuffelRudi Beyaert
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Aug 31, 2018·Frontiers in Immunology·J Randall McAuleyLinda M McAllister-Lucas
Sep 3, 2019·Frontiers in Immunology·Annelies DemeyerRudi Beyaert
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