Targeting MET Dysregulation in Cancer.

Cancer Discovery
Gonzalo RecondoMark M Awad

Abstract

Aberrant MET signaling can drive tumorigenesis in several cancer types through a variety of molecular mechanisms including MET gene amplification, mutation, rearrangement, and overexpression. Improvements in biomarker discovery and testing have more recently enabled the selection of patients with MET-dependent cancers for treatment with potent, specific, and novel MET-targeting therapies. We review the known oncologic processes that activate MET, discuss therapeutic strategies for MET-dependent malignancies, and highlight emerging challenges in acquired drug resistance in these cancers. SIGNIFICANCE: Increasing evidence supports the use of MET-targeting therapies in biomarker-selected cancers that harbor molecular alterations in MET. Diverse mechanisms of resistance to MET inhibitors will require the development of novel strategies to delay and overcome drug resistance.

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Citations

Oct 6, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xuanzong LiLinlin Wang
Dec 11, 2020·The Cancer Journal·Biagio Ricciuti, Mark M Awad
Apr 17, 2021·Biochemical Society Transactions·Edmond M LinossiNatalia Jura
May 8, 2021·Expert Review of Anticancer Therapy·Janakiraman Subramanian, Ossama Tawfik
May 23, 2021·Revue des maladies respiratoires·C BasseN Girard
Aug 15, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Di LiuMin Fan

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