Targeting metabotropic glutamate receptors for the treatment of neuroinflammation

Current Opinion in Pharmacology
Francesco FazioFrancesca Fallarino

Abstract

A large body of evidence suggests that neuroinflammation lies at the core of nearly all CNS disorders, including psychiatric disorders. Invading and local immune cells orchestrate the series of events that lead to either tissue repair or damage in response to neuroinflammation. Both lymphocytes and microglia express metabotropic glutamate (mGlu) receptors, which respond to glutamate or other endogenous activators (e.g. some kynurenine metabolites of tryptophan metabolism) influencing immune phenotype and the balance between pro-inflammatory and anti-inflammatory cytokines. Here, we offer an up-to-date on the role of individual mGlu receptor subtypes in the regulation of innate and adaptive immune response, highlighting the relevance of this information in the development of subtype-selective mGlu receptor ligands for treatment of CNS disorders.

Citations

Dec 6, 2018·International Journal of Molecular Sciences·Ivan PrestaGiuseppe Donato
May 8, 2020·Cells·Md Abdul AlimGunnar Pejler
Oct 16, 2018·Frontiers in Cellular Neuroscience·Zsuzsanna SzepesiTomas Deierborg
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Jan 22, 2019·Frontiers in Molecular Neuroscience·Vanessa Pereira, Cyril Goudet
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Apr 27, 2021·Pharmacology & Therapeutics·Cong-Yuan XiaWei-Ku Zhang
May 30, 2021·Psychoneuroendocrinology·Wansu QiuLiisa A M Galea

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