Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

Oncotarget
Kimberly A BirnieSteven E Mutsaers

Abstract

Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced stage and current treatments are limited. Identifying new diagnostic and therapeutic targets for mesothelioma remains a priority, particularly for the new wave of victims exposed to asbestos through do-it-yourself renovations and in countries where asbestos is still mined and used. Recent advances have demonstrated a biological role for the small but powerful gene regulators microRNA (miRNA) in mesothelioma. A number of potential therapeutic targets have been identified. MiRNA have also become popular as potential biomarkers for mesothelioma due to their stable expression in bodily fluid and tissues. In this review, we highlight the current challenges associated with the diagnosis and treatment of mesothelioma and discuss how targeting miRNA may improve diagnostic, prognostic and therapeutic approaches.

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Citations

Aug 14, 2019·Scientific Reports·Phillip B MunsonArti Shukla
Sep 16, 2020·Cell Death & Disease·Caterina CostaAntonio Giordano
Sep 5, 2019·Disease Markers·Kimberly A BirnieSteven E Mutsaers
Jan 10, 2019·Frontiers in Oncology·Giuseppe Lo RussoDario Palmieri
Jan 20, 2021·Cancer Cytopathology·Albino EccherLiron Pantanowitz
Jul 13, 2021·Frontiers in Oncology·Stefanie HiltbrunnerFederica Grosso

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Methods Mentioned

BETA
biopsy
PCR
Chromosomal aberration
transfection
affinity purification
xenograft
chromosomal aberrations

Clinical Trials Mentioned

NCT02369198

Software Mentioned

EnGeneIC

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