Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Brain Communications
Arpan R MehtaJenna M Gregory

Abstract

Interventions targeting mitochondrial dysfunction have the potential to extend survival in preclinical models of amyotrophic lateral sclerosis. The aim of this systematic review was to assess the efficacy of targeting mitochondria as a potential therapeutic target in amyotrophic lateral sclerosis. Preclinical studies written in the English language were identified with no restrictions on publication date from PubMed, Medline and EMBASE databases. All studies adopting interventions targeting mitochondria to treat amyotrophic lateral sclerosis in genetic or drug-induced organism models were considered for inclusion. A total of 76 studies were included in the analysis. Survival data were extracted, and the meta-analysis was completed in RevMan 5 software. We show that targeting mitochondrial dysfunction in amyotrophic lateral sclerosis results in a statistically significant improvement in survival (Z = 5.31; P<0.00001). The timing of administration of the intervention appears to affect the improvement in survival, with the greatest benefit occurring for interventions given prior to disease onset. Interventions at other time points were not significant, although this is likely to be secondary to a lack of publications examining the...Continue Reading

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Citations

Mar 7, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Lu XuDongsheng Fan
Aug 21, 2020·Acta Neuropathologica Communications·Koy Chong Ng Kee KwongSiddharthan Chandran
Sep 22, 2020·Brain Communications·Tara L Spires-Jones
Jun 17, 2021·Cell Reports·Triana Amen, Daniel Kaganovich
Jul 3, 2021·International Journal of Molecular Sciences·Elena ObradorJosé M Estrela

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Methods Mentioned

BETA
transgenic

Software Mentioned

Review Manager
mito
RevMan
QC

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