Targeting Mitochondrial Ion Channels to Fight Cancer

International Journal of Molecular Sciences
Magdalena BachmannLuigi Leanza

Abstract

In recent years, several experimental evidences have underlined a new role of ion channels in cancer development and progression. In particular, mitochondrial ion channels are arising as new oncological targets, since it has been proved that most of them show an altered expression during tumor development and the pharmacological targeting of some of them have been demonstrated to be able to modulate cancer growth and progression, both in vitro as well as in vivo in pre-clinical mouse models. In this scenario, pharmacology of mitochondrial ion channels would be in the near future a new frontier for the treatment of tumors. In this review, we discuss the new advances in the field, by focusing our attention on the improvements in new drug developments to target mitochondrial ion channels.

References

Jul 1, 1979·Archives of Biochemistry and Biophysics·R A Haworth, D R Hunter
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B D GelbE R McCabe
Dec 11, 1987·Biochimica Et Biophysica Acta·M ColombiniT König
Jan 1, 1987·The Journal of Membrane Biology·H TedeschiC L Bowman
Dec 1, 1982·Journal of Bioenergetics and Biomembranes·T KönigF Palmieri
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Apr 1, 1995·The Biochemical Journal·E J Griffiths, A P Halestrap
May 20, 1996·FEBS Letters·V Shoshan-BarmatzL M Heilmeyer
Apr 1, 1996·Journal of Bioenergetics and Biomembranes·W H Yu, M Forte
Jan 20, 1998·Die Naturwissenschaften·F P Thinnes, S Reymann
Apr 17, 1998·European Journal of Pharmacology·J Penso, R Beitner
Jun 30, 1998·Pflügers Archiv : European journal of physiology·S ReymannF P Thinnes
Apr 13, 1999·Biochemical and Biophysical Research Communications·D SiemenF Lang
Mar 29, 2000·The Journal of Biological Chemistry·Y KimD Kim
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ShimizuY Tsujimoto
Oct 18, 2000·Free Radical Biology & Medicine·J ChandraS Orrenius
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·J C Martinou, D R Green
Dec 26, 2001·The Journal of Biological Chemistry·John G PastorinoJan B Hoek
Jan 5, 2002·Journal of Bioenergetics and Biomembranes·G BáthoriM Zoratti
Feb 12, 2002·Nature Reviews. Neuroscience·Senyon Choe
May 29, 2002·Nuclear Medicine and Biology·Raya S BrownRichard L Wahl
Aug 7, 2002·Antisense & Nucleic Acid Drug Development·Richard J KlasaStanley R Frankel
Aug 7, 2002·British Journal of Pharmacology·Maria Pia RigobelloAlberto Bindoli
Mar 26, 2003·Journal of Cellular Physiology·Yoshihide Tsujimoto
Jun 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lin PeiTimothy Hoey
Jun 20, 2003·The Journal of Physiology·Sulayma AlbarwaniNancy J Rusch
Jan 20, 2004·The Journal of Biological Chemistry·Tatiana K RostovtsevaSergey M Bezrukov

❮ Previous
Next ❯

Citations

Mar 3, 2019·Cancers·Clara Serrano-NovilloAntonio Felipe
Oct 16, 2019·Frontiers in Oncology·Andrzej TeisseyreKrystyna Michalak
Dec 4, 2020·BMC Cancer·Azer FarahBalkiss Bouhaouala-Zahar
May 1, 2021·Pharmacology & Therapeutics·Vanessa ChecchettoIldiko Szabo
Jun 11, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ao LuChengdang Wang
Jul 25, 2021·International Journal of Molecular Sciences·Xuan WangJunjie Luo

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Medicine : Journal of the Royal College of Physicians of London
K S El-Haddad, A R Padhani
© 2022 Meta ULC. All rights reserved