Targeting mTOR in Acute Lymphoblastic Leukemia

Cells
C SimioniL M Neri

Abstract

Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients have a favourable prognosis, with 5-years overall survival rates near 90%, while adult ALL still correlates with poorer survival. However, during the past few decades, the therapeutic outcome of adult ALL was significantly ameliorated, mainly due to intensive pediatric-based protocols of chemotherapy. Mammalian (or mechanistic) target of rapamycin (mTOR) is a conserved serine/threonine kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase family (PIKK) and resides in two distinct signalling complexes named mTORC1, involved in mRNA translation and protein synthesis and mTORC2 that controls cell survival and migration. Moreover, both complexes are remarkably involved in metabolism regulation. Growing evidence reports that mTOR dysregulation is related to metastatic potential, cell proliferation and angiogenesis and given that PI3K/Akt/mTOR network activation is often associated with poor prognosis and chemoresistance in ALL, there is a constant need to discover novel inhibitors for ALL treatment. Here, the current knowledge of mTOR sig...Continue Reading

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Citations

Jun 23, 2019·International Journal of Molecular Sciences·Elena FolliniGiovanni Roti
Sep 25, 2019·Cells·Xiangyong WeiJinzi Chen
May 13, 2020·Cardiovascular Drugs and Therapy·Xing ChenShiming Liu
Oct 2, 2019·Cancers·Francesca CuomoGilda Cobellis
Oct 18, 2020·Cells·Shile Huang
Aug 5, 2020·Molecular Cancer Therapeutics·Joy M GaryBeverly A Mock
Mar 7, 2021·Journal of Clinical Laboratory Analysis·Elham RoshandelSayeh Parkhideh
Mar 19, 2021·Frontiers in Cell and Developmental Biology·Dong-Hu YuXiao-Lan Ruan
Apr 4, 2021·International Journal of Molecular Sciences·Princess D RodriguezSeth Frietze
Jun 26, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Fang-Liang HuangChia-Ling Li

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Methods Mentioned

BETA
GTPase
ChIP-seq
RNA-seq
xenografts
xenograft

Clinical Trials Mentioned

NCT02435849
NCT03263572
NCT00968253
NCT01614197
NCT00792948
NCT01403415
NCT01523977
NCT03328104
NCT01756118

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