Targeting MYC in cancer therapy: RNA processing offers new opportunities

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Cheryl M KohErnesto Guccione

Abstract

MYC is a transcription factor, which not only directly modulates multiple aspects of transcription and co-transcriptional processing (e.g. RNA-Polymerase II initiation, elongation, and mRNA capping), but also indirectly influences several steps of RNA metabolism, including both constitutive and alternative splicing, mRNA stability, and translation efficiency. As MYC is an oncoprotein whose expression is deregulated in multiple human cancers, identifying its critical downstream activities in tumors is of key importance for designing effective therapeutic strategies. With this knowledge and recent technological advances, we now have multiple angles to reach the goal of targeting MYC in tumors, ranging from the direct reduction of MYC levels, to the dampening of selected house-keeping functions in MYC-overexpressing cells, to more targeted approaches based on MYC-induced secondary effects.

References

Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I B RosenwaldE V Schmidt
Jan 24, 1998·The Journal of Biological Chemistry·C NanbruA C Prats
Jun 4, 1999·Antisense & Nucleic Acid Drug Development·R V GilesD M Tidd
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·B M Iritani, R N Eisenman
Jun 18, 2002·Current Opinion in Cell Biology·Witold Filipowicz, Vanda Pogacić
Jan 17, 2003·Nature·Natividad Gomez-RomanRobert J White
Jul 30, 2004·The EMBO Journal·Gretchen PoortingaRoss D Hannan
Oct 20, 2004·Cell Cycle·Lorenzo Montanaro, Pier Paolo Pandolfi
Feb 22, 2005·Nature Cell Biology·Azadeh ArabiAnthony P H Wright
Feb 22, 2005·Nature Cell Biology·Savraj S GrewalBruce A Edgar
Oct 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sabine RottmannKim C Quon
Apr 22, 2006·Biochemical Society Symposium·Natividad Gomez-RomanRobert J White
Jun 13, 2006·Nature Cell Biology·Ernesto GuccioneBruno Amati
Mar 10, 2007·Journal of Medicinal Chemistry·Tian-Miao OuLian-Quan Gu
Apr 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Khandaker SiddiqueeJames Turkson
Jun 26, 2007·Nature Medicine·Andrei GogaJ Michael Bishop
Jul 7, 2007·Cancer Cell·David A Guertin, David M Sabatini
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Niall S KennethRobert J White
Nov 13, 2007·Molecular Cell·Steve BraunsteinRobert J Schneider
Dec 11, 2007·Nature Genetics·Tsung-Cheng ChangJoshua T Mendell
Dec 22, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Harmanjatinder S SekhonGayathri R Devi
Feb 19, 2008·Cancer Research·Jack ZhangG Tim Bowden
Mar 29, 2008·American Journal of Human Genetics·Yimin HuaAdrian R Krainer
Jul 24, 2008·Journal of the National Cancer Institute. Monographs·David Levens
Aug 22, 2008·Nature·Laura SoucekGerard I Evan
Nov 26, 2008·RNA·Doreen WeidensdorferStefan Hüttelmaier
Oct 7, 2009·Molecular and Cellular Biology·Maria Elena Fernandez-SanchezVictoria H Cowling
Dec 17, 2009·Nature Cell Biology·Stefano CampanerBruno Amati
Jan 28, 2010·Cancer Prevention Research·TachaZi Plym ForshellJonas A Nilsson

❮ Previous
Next ❯

Citations

Mar 11, 2017·Frontiers in Cell and Developmental Biology·Jonathan R WhitfieldLaura Soucek
Apr 1, 2017·Genes·Himalee S SabnisKevin D Bunting
Jul 13, 2017·Bioconjugate Chemistry·Fumiko Chiba, Lance J Twyman
Dec 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia Rizeq, Savvas N Georgiades
Mar 3, 2018·International Journal of Molecular Sciences·Lucie CoppinPascal Pigny
Jan 3, 2018·The Journal of Pathology·Amal M El-Naggar, Poul H Sorensen
Jul 29, 2017·British Journal of Pharmacology·Yung LyouMarian L Waterman
Feb 23, 2018·Leukemia·K K JovanovićS Manier
Aug 29, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasutaka YamadaNaohiko Seki
Nov 9, 2018·The Journal of Biological Chemistry·André S Bachmann, Dirk Geerts
Mar 16, 2019·Immunological Reviews·Andrea BissoBruno Amati
Jun 21, 2020·Journal of Biochemical and Molecular Toxicology·Soon-Kyung HwangYoung-Chae Chang
Oct 16, 2018·Frontiers in Oncology·Giuseppe BiamontiAlessandra Montecucco
Jun 30, 2018·Nature Reviews. Clinical Oncology·Alan Ashworth, Christopher J Lord
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lavinia A CarabetArtem Cherkasov
Aug 16, 2018·European Journal of Human Genetics : EJHG·Michael HubbertenArne S Schaefer
Jun 18, 2017·Biochemical Society Transactions·Richard BaylissMark W Richards
Jan 2, 2019·International Journal of Molecular Sciences·Lavinia A CarabetArtem Cherkasov
Nov 5, 2020·International Journal of Molecular Sciences·Ling-Yu HuangTze-Ta Huang
Jul 14, 2016·Molecular Cancer Therapeutics·Matthias WirthGünter Schneider
Mar 16, 2021·Frontiers in Oncology·Jeyshka M Reyes-González, Pablo E Vivas-Mejía
Jun 4, 2021·BMC Complementary Medicine and Therapies·Seth A DomfehMohamed Mutocheluh
Jun 11, 2021·Frontiers in Cell and Developmental Biology·Ran ZhaoMing Zhou
Sep 12, 2021·Nature Reviews. Clinical Oncology·Renumathy DhanasekaranDean W Felsher

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
antisense oligonucleotides
antisense oligonucleotide

Software Mentioned

Omomyc

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Bo Li, M Celeste Simon
Epigenomics
Sérgio Fernandes de Almeida, Maria Carmo-Fonseca
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Mengmeng Ji, Weili Zhao
© 2022 Meta ULC. All rights reserved