Targeting MYC in multiple myeloma

Leukemia
K K JovanovićSalomon Manier

Abstract

Multiple myeloma (MM) is a plasma cell tumor marked by clonal evolution and preceded by a premalignant stage, which progresses via molecular pathway deregulation, including MYC activation. This activation relates to translocation or gain of the MYC locus and deregulation of upstream pathways such as IRF4, DIS3/LIN28B/let-7, or MAPK. Precision medicine is an approach to predict more accurately which treatment strategies for a particular disease will work in which groups of patients, in contrast to a "one-size-fits-all" approach. The knowledge of mechanisms responsible for MYC deregulation in MM enables identification of vulnerabilities and therapeutic targets in MYC-driven tumors. MYC can be targeted directly or indirectly, by interacting with several of its functions in cancer. Several such therapeutic strategies are evaluated in clinical trials in MM. In this review, we describe the mechanism of MYC activation in MM, the role of MYC in cancer progression, and the therapeutic options to targeting MYC.

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Apr 16, 2019·European Journal of Haematology·Yu-Shan CuiBai-Jun Fang
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Methods Mentioned

BETA
transgenic
immunoprecipitation
ubiquitination
xenograft

Clinical Trials Mentioned

NCT02110563
NCT01713582
NCT02157636
NCT03068351
NCT02867618
NCT02784483
NCT02220842
NCT02807454
NCT03000452
NCT03003520

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