Targeting Myeloid-Derived Suppressor Cell, a Promising Strategy to Overcome Resistance to Immune Checkpoint Inhibitors.

Frontiers in Immunology
Aohan HouWanling Chen

Abstract

Immune checkpoint inhibitors (ICIs) are starting to transform the treatment for patients with advanced cancer. The extensive application of these antibodies for various cancer obtains exciting anti-tumor immune response by activating T cells. Although the encouraging clinical benefit in patients receiving these immunostimulatory agents are observed, numbers of patients still derive limited response or even none for reasons unknown, sometimes at the cost of adverse reactions. Myeloid-derived suppressor cells (MDSCs) is a heterogeneous immature population of myeloid cells partly influencing the efficacy of immunotherapies. These cells not only directly suppress T cell but mediate a potently immunosuppressive network within tumor microenvironment to attenuate the anti-tumor response. The crosstalk between MDSCs and immune cells/non-immune cells generates several positive feedbacks to negatively modulate the tumor microenvironment. As such, the recruitment of immunosuppressive cells, upregulation of immune checkpoints, angiogenesis and hypoxia are induced and contributing to the acquired resistance to ICIs. Targeting MDSCs could be a potential therapy to overcome the limitation. In this review, we focus on the role of MDSCs in resi...Continue Reading

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Citations

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Sep 19, 2020·Cancers·Yufei WangGuangwei Liu
Nov 27, 2020·Frontiers in Immunology·Isaac Rosado-SánchezYolanda María Pacheco
Jan 8, 2021·Cancer Metastasis Reviews·Kathryn ColeJames E Talmadge
Jan 7, 2021·Cell Reports·Peiwen ChenRonald A DePinho
Jan 11, 2021·Journal of Experimental & Clinical Cancer Research : CR·Bin WangXin Jiang
May 1, 2021·Journal of Clinical Medicine·Alejandro Olivares-HernándezJosé Pablo Miramontes-González
Jul 18, 2021·Trends in Cell Biology·Wenjing XuanPeiwen Chen
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Sep 18, 2021·Frontiers in Immunology·Isak W TengesdalCharles A Dinarello
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Datasets Mentioned

BETA
GMDSCs

Methods Mentioned

BETA
flow cytometry
biopsies
xenograft

Clinical Trials Mentioned

NCT04193293
NCT04118855
NCT03959293
NCT03768531
NCT03736330
NCT03581487
NCT03516279
NCT03332498
NCT03202758
NCT03086174

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