Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy.

Mediators of Inflammation
Chao ChenCong Peng

Abstract

Psoriasis is a common immune-mediated, chronic inflammatory genetic-related disease that affects patients' quality of life. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of progenitor and immature myeloid cells which are expanded in psoriatic skin lesions and peripheral blood. However, the role of MDSCs in the pathogenesis of psoriasis remains unclear. Here, we confirmed that the accumulation of human MDSCs is remarkably increased in skin lesions of psoriasis patients by flow cytometry. Depleting MDSCs by Gemcitabine significantly suppresses IMQ-induced psoriatic inflammation and epidermal thickening as well as Th17 and Treg cell accumulation. Moreover, through the RNA-Seq technique, we validated some differentially expressed genes on CD4+ T-cells of IMQ-induced-MDSC-depleted mice such as IL-21 and Timd2, which are involved in Th17-cell differentiation or T-cell activation. Interestingly, neutralizing IL-21R by antibody reduces IMQ-induced epidermal thickening through downregulating the infiltration of MDSCs and Th17 cells. Our data suggest that targeting myeloid-derived suppressor cells is a novel strategy for antipsoriasis therapy. IL-21 may be a potential therapeutic target in psoriasis.

References

Mar 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L AbbruzzeseM N Raber
Jul 1, 1994·Cellular Immunology·A HaregewoinR W Finberg
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joachim LehmannAlf Hamann
May 31, 2003·Nature Reviews. Immunology·Vijay K KuchrooGordon J Freeman
Jan 7, 2004·The Journal of Experimental Medicine·Edmund LeeJames G Krueger
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eiji SuzukiSteven M Albelda
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Aug 18, 2009·Nature Medicine·Roberta CarusoGiovanni Monteleone
Dec 17, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Li ZhangTian-Wen Gao
Jan 26, 2010·Actas dermo-sifiliográficas·R K H MakF O Nestle
Dec 18, 2010·Annals of Dermatology·Woo-Jin YunJee-Ho Choi
Jun 10, 2011·The Journal of Investigative Dermatology·H Jorn BovenschenHans J P M Koenen
Aug 17, 2011·The Journal of Investigative Dermatology·David C Soler, Thomas S McCormick
Nov 8, 2011·Annual Review of Pathology·Gayathri K PereraFrank O Nestle
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
Aug 4, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Isabel Poschke, Rolf Kiessling
Oct 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huanfa YiXiang-Yang Wang
Dec 24, 2013·Nature Medicine·Noriko KomatsuHiroshi Takayanagi
Feb 11, 2014·The Journal of Clinical Investigation·Robert Sanchez RodriguezMichael D Rosenblum
Mar 25, 2014·Annual Review of Immunology·Michelle A LowesJames G Krueger
Feb 15, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hui ZhangShu Man Fu
May 31, 2015·Lancet·Wolf-Henning Boehncke, Michael P Schön
Dec 19, 2015·Scandinavian Journal of Immunology·L ZhangC Feng
May 29, 2016·The Journal of Investigative Dermatology·Lauren Y CaoKiyoshi Ariizumi
Oct 30, 2016·The Journal of Investigative Dermatology·Kave ShamsGerard J Graham
Aug 31, 2016·Molecular Medicine Reports·Dan Ilkovitch, Laura K Ferris
Apr 6, 2017·EMBO Molecular Medicine·Huiyuan ZhuHonglin Wang
Apr 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomonori OkaShinichi Sato
Jun 19, 2017·Journal of the American Academy of Dermatology·Kelly M CordoroMichael D Rosenblum
Oct 27, 2017·Journal of the American Academy of Dermatology·Amy S PallerEmma Guttman-Yassky
Jan 20, 2018·Nature Immunology·Filippo VegliaDmitry Gabrilovich
Dec 28, 2018·Cell Reports·Tom HartwigBurkhard Becher
Feb 19, 2019·Journal of Autoimmunity·Di LongQianjin Lu

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Methods Mentioned

BETA
flow cytometry
PMA
FACS
RNA-seq

Software Mentioned

GEM
FlowJo ( Tree Star )
GraphPad
GSEA
GraphPad Prism

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