Targeting NEU Protein in Melanoma Cells with Non-Thermal Atmospheric Pressure Plasma and Gold Nanoparticles

Journal of Biomedical Nanotechnology
Byul Bora ChoiG C Kim

Abstract

Non-thermal atmospheric pressure plasma effectively kills cancer cells, but it cannot selectively kill cancer cells. The authors targeted NEU (human epidermal growth factor receptor 2) protein, which is frequently over-expressed in the cell membrane of melanoma cells, using anti-NEU antibody-labeled gold nanoparticles. The labeled nanoparticles preferentially targeted melanoma cells rather than normal keratinocytes. After the addition of labeled gold nanoparticles to melanoma and normal keratinocyte cells, both cells were exposed to non-thermal atmospheric pressure plasma. The death rate of melanoma cells was significantly higher than that of normal keratinocyte cells; many vacuoles, indicative of cell death, were observed in melanoma cells treated with anti-NEU antibody labeled gold nanoparticles and plasma. This selective cancer cell death was attributed to the selective destruction of NEU protein and a downstream effector of NEU. Our study findings show that treatment with a combination of non-thermal atmospheric pressure plasma and anti-NEU antibody-labeled gold nanoparticles effectively and selectively kills melanoma cells.

Citations

Feb 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Adam M HirstDeborah O'Connell
Jan 28, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Salman BagheriHamid Kooshki
Aug 11, 2018·Journal of Cancer Research and Clinical Oncology·Harshita MishraSushama Talegaonkar
Jan 17, 2019·Nanomaterials·Nagendra Kumar KaushikEun Ha Choi

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