Targeting neurotrophin signaling in cancer: The renaissance

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Nathan GriffinHubert Hondermarck

Abstract

Nerve outgrowth in the tumor microenvironment (tumor neurogenesis) has recently been shown to be essential for cancer progression and the concept of nerve dependence is emerging in oncology. Neurotrophins such as nerve growth factor (NGF) have long been identified as drivers of neurogenesis during development and regeneration, but intriguingly they were also known to be expressed in human tumors where they can stimulate cancer cell growth. Recent findings have unraveled that NGF released by cancer cells is also a driver of tumor neurogenesis, via the stimulation of NGF receptors on nerve endings. In return, nerves infiltrated in the tumor microenvironment secrete neurotransmitters, which can stimulate both the growth of tumor cells and angiogenesis. This neurotrophic role of NGF in cancer is likely to be relevant to a large variety of human malignancies, as well as other neurotrophins, and may have ramifications in cancer pain. Therefore, pharmacological interventions against neurotrophin signaling have the potential not only to target cancer cells directly, but also to inhibit neurogenesis and its stimulatory impact on cancer progression and pain.

Citations

Sep 4, 2018·FEBS Letters·David Villarroel-CamposOscar Marcelo Lazo
Sep 19, 2019·Oncogene·Shu-Heng JiangZhi-Gang Zhang
Feb 23, 2020·Epigenomics·Chenxi ZhangXiaoyuan Wu
Jan 25, 2020·Nature Reviews. Cancer·Ali H Zahalka, Paul S Frenette
Feb 6, 2020·Frontiers in Oncology·Veronica FioritoEmanuela Tolosano
Jan 16, 2020·Nature Reviews. Urology·Brayden MarchHubert Hondermarck
Jan 11, 2020·Frontiers in Oncology·Wei MuMargot Zöller
Feb 1, 2020·Scientific Reports·Christopher W RoweHubert Hondermarck
Apr 5, 2019·Cancer Discovery·Sam FaulknerHubert Hondermarck
Jan 23, 2021·Neuroscience Letters·Patrick J HuntMoran Amit
Aug 23, 2020·Immunology Letters·Nina CorteseFederica Marchesi
Jul 3, 2021·Life·Anna PerriAntonio Aversa
Jul 17, 2021·Frontiers in Cell and Developmental Biology·Marzia Di DonatoGabriella Castoria
Aug 3, 2021·Frontiers in Neuroscience·Giuseppe AlastraGiovanni Tosi
Jun 2, 2020·The American Journal of Pathology·Nathan GriffinHubert Hondermarck

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