Targeting nitric oxide to its targets

Proceedings of the Society for Experimental Biology and Medicine
D S Bredt

Abstract

Nitric oxide (NO) is now recognized as a major messenger molecule in the nervous system. In specific neuronal pathways, NO functions alternatively as a neurotransmitter and as a second messenger. Neuronal-type nitric oxide synthase is a widely distributed (nNOS or Type I) calmodulin-regulated enzyme and is coupled to a variety of neurotransmitter systems in brain and peripheral tissues. NO formation is linked in cerebellum to NMDA receptor activity, in myenteric neurons to neuronal nicotinic receptor activity, and in skeletal muscle to sarcolemmal depolarization. Coupling of nNOS activity to alternative calcium sources appears to be mediated, in part, by tethering nNOS to specific membrane proteins. In skeletal muscle, nNOS physically associates with the sarcolemmal dystrophin complex through a GLGF protein-association motif present near the N terminus of nNOS. This GLGF motif is likely also involved in anchoring nNOS to synaptic membrane complexes in brain. Subcellular targeting of nNOS represents a crucial mechanism for regulation of NO actions in the nervous system.

Citations

Jun 1, 1997·Invertebrate Neuroscience : in·J W Jacklet
Oct 24, 2002·Neurobiology of Aging·Eugenio E MullerSilvano G Cella
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Feb 9, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M S Hedrick, R D Morales
Aug 1, 2002·The Laryngoscope·Tsan-Ju ChenYueh-Ling Hsieh
Apr 1, 2007·Pakistan Journal of Biological Sciences : PJBS·M NobakhtP Tabatabaeei
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A J KanaiJ Peterson
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·A HausladenJ S Stamler
Dec 18, 2001·Microscopy Research and Technique·D Blottner, G Lück
Jul 15, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Anbar, B M Gratt
May 26, 2004·Nitric Oxide : Biology and Chemistry·Eduardo Sánchez-Islas, Martha León-Olea
Feb 24, 2015·Frontiers in Medicine·Arun Chaudhury
Nov 26, 2016·Expert Opinion on Therapeutic Targets·Neeru M Sharma, Kaushik P Patel
Aug 23, 2000·Biology of Reproduction·N F Gonzalez-CadavidJ Rajfer
Mar 5, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Chana A RabinerBetty A Eipper
Feb 19, 2000·Microscopy Research and Technique·J A Rafael, S C Brown
Jan 5, 1999·The Journal of Biological Chemistry·E A RatovitskiC J Lowenstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.