Targeting Nrf2 in Protection Against Renal Disease

Current Medicinal Chemistry
Melania Guerrero-HueJuan A Moreno

Abstract

Renal disease is a serious health problem, with increasing incidence and prevalence. Oxidative stress and inflammation play a key role in the pathogenesis and progression of renal disease. Therefore, therapeutic approaches to decrease oxidative stress should be of interest. This review aims to provide a comprehensive and updated overview of the protective mechanisms mediated by Nrf2 (nuclear factor erythroid 2-related factor 2), a description of novel compounds that target Nrf2, its effectiveness to prevent renal disease and the on-going clinical trials for this pathological condition. We undertook a structured search of bibliographic databases for peer-reviewed research in literature about Nrf2 activators and renal disease. The transcription factor Nrf2 is an emerging regulator of cellular resistance to oxidants and inflammation. Nrf2 controls the basal and induced expression of a couple of cytoprotective and antiinflammatory genes that regulate the physiological and pathophysiological outcomes of oxidant exposure. We have analyzed numerous findings showing that Nrf2 induction protects against oxidative stress and modulates inflammation in acute kidney injury and chronic kidney disease progression. However, few clinical trials...Continue Reading

Citations

Apr 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melania Guerrero-HueJuan Antonio Moreno
Feb 16, 2020·Journal of Biochemical and Molecular Toxicology·Durgesh K DwivediVinod Kumar
Dec 6, 2017·The Journal of Pathology·Alfonso Rubio-NavarroJuan Antonio Moreno
May 31, 2020·International Journal of Molecular Sciences·Sandra Rayego-MateosJesús Egido
Jul 25, 2019·Frontiers in Pharmacology·Alfonso Rubio-NavarroJuan Antonio Moreno
Aug 3, 2019·Archives of Pharmacal Research·Cody J SchmidlinDonna D Zhang
Apr 30, 2019·Frontiers in Pharmacology·Rafael M da CostaRita C Tostes
Mar 15, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Salvador Payán-PerníaJuan Antonio Moreno

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