Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies.

Signal Transduction and Targeted Therapy
Miaoqin ChenLifeng Feng

Abstract

Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer treatment. However, there are many patients who failed to benefit from these therapies, highlighting the need for new combinations to increase the clinical efficacy of immune checkpoint inhibitors. In this review, we summarized the latest discoveries on the combination of nucleic acid-sensing immunity and immune checkpoint inhibitors in cancer immunotherapy. Given the critical role of nuclear acid-mediated immunity in maintaining the activation of T cell function, it seems that harnessing the nuclear acid-mediated immunity opens up new strategies to enhance the effect of immune checkpoint inhibitors for tumor control.

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Citations

Mar 7, 2021·Non-coding RNA·Shaymaa SadeqAndreas Werner
Oct 29, 2021·Journal of Clinical and Experimental Hematopathology : JCEH·Norimitsu Kadowaki

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Methods Mentioned

BETA
ubiquitination
nuclear translocation

Clinical Trials Mentioned

NCT03065023
NCT03739138
NCT03599453
NCT03734692
NCT04119830
NCT04093323
NCT02834052
NCT03721679
NCT04024878
NCT03633110

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