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Targeting of breast metastases using a viral gene vector with tumour-selective transcription

Anticancer Research

May 28, 2011

Simon RajendranMark Tangney

PMID: 21617219

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Abstract

Adeno-associated virus (AAV) vectors have significant potential as gene delivery vectors for cancer gene therapy. However, broad AAV2 tissue tropism results in nonspecific gene expression. We investigated use of the C-X-C chemokine receptor type 4 (CXCR4) promoter to restrict AAV expres...read more

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Flow Cytometry
Shuttle Vectors
Gene Transfer Techniques
Virus Diseases
CXCR4 gene
Adeno-Associated Virus
Transcription, Genetic
Neoplasms
Tumor Lysis Syndrome
Paper Details
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Targeting of breast metastases using a viral gene vector with tumour-selective transcription

Anticancer Research

May 28, 2011

Simon RajendranMark Tangney

PMID: 21617219

DOI:

Abstract

Adeno-associated virus (AAV) vectors have significant potential as gene delivery vectors for cancer gene therapy. However, broad AAV2 tissue tropism results in nonspecific gene expression. We investigated use of the C-X-C chemokine receptor type 4 (CXCR4) promoter to restrict AAV expres...read more

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Flow Cytometry
Shuttle Vectors
Gene Transfer Techniques
Virus Diseases
CXCR4 gene
Adeno-Associated Virus
Transcription, Genetic
Neoplasms
Tumor Lysis Syndrome

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CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

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Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición

Adeno-associated viral vectors: methods for production and purification for gene therapy applications

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Paper Details
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