Targeting of histamine producing cells by EGCG: a green dart against inflammation?

Journal of Physiology and Biochemistry
Esther MelgarejoJosé Luis Urdiales

Abstract

The human body is made of some 250 different cell types. From them, only a small subset of cell types is able to produce histamine. They include some neurons, enterochromaffin-like cells, gastrin-containing cells, mast cells, basophils, and monocytes/macrophages, among others. In spite of the reduced number of these histamine-producing cell types, they are involved in very different physiological processes. Their deregulation is related with many highly prevalent, as well as emergent and rare diseases, mainly those described as inflammation-dependent pathologies, including mastocytosis, basophilic leukemia, gastric ulcer, Crohn disease, and other inflammatory bowel diseases. Furthermore, oncogenic transformation switches some non-histamine-producing cells to a histamine producing phenotype. This is the case of melanoma, small cell lung carcinoma, and several types of neuroendocrine tumors. The bioactive compound epigallocatechin-3-gallate (EGCG), a major component of green tea, has been shown to target histamine-producing cells producing great alterations in their behavior, with relevant effects on their proliferative potential, as well as their adhesion, migration, and invasion potentials. In fact, EGCG has been shown to have ...Continue Reading

References

May 1, 1992·Preventive Medicine·H N Graham
Jan 1, 1987·Free Radical Research Communications·W Bors, M Saran
Jun 5, 1997·Nature·J JankunE Skrzypczak-Jankun
Mar 11, 1998·Current Opinion in Immunology·R SaccaN H Ruddle
Jan 1, 1997·Journal of Cellular Biochemistry. Supplement·S K Katiyar, H Mukhtar
Apr 14, 1999·Nature·Y Cao, R Cao
Jul 2, 1999·The American Journal of Medicine·L S Simon
Jul 15, 1999·Journal of Hypertension·J M HodgsonN Jordan
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MenegazziH Suzuki
Feb 13, 2002·Journal of the American College of Nutrition·Diane L McKay, Jeffrey B Blumberg
May 3, 2002·Nutrition·Christine D Wu, Guo-Xian Wei
Jul 4, 2002·International Immunopharmacology·E AlvarezF Orallo
Oct 3, 2002·Biochemical and Biophysical Research Communications·John J Haddad
Dec 18, 2002·Annals of the New York Academy of Sciences·E TedeschiM Menegazzi
Mar 12, 2003·Mutation Research·Joshua D Lambert, Chung S Yang
Mar 19, 2003·Critical Reviews in Biochemistry and Molecular Biology·Miguel Angel MedinaFrancisca Sánchez-Jiménez
Oct 3, 2003·Cellular and Molecular Life Sciences : CMLS·C Rodríguez-CasoM A Medina
Mar 17, 2004·Nature Structural & Molecular Biology·Hirofumi TachibanaKoji Yamada
Mar 23, 2004·Biochemical and Biophysical Research Communications·Antje LudwigVerena Stangl
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Orhan AktasFrauke Zipp
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Kazushige KawaiHirokazu Nagawa
Jan 11, 2005·The American Journal of Clinical Nutrition·Joshua D LambertChung S Yang
Apr 4, 2006·Journal of the American College of Nutrition·Carmen CabreraRafael Giménez
Jul 26, 2006·Free Radical Biology & Medicine·Biji T KurienR Hal Scofield
Jan 18, 2007·Journal of Agricultural and Food Chemistry·Yoko NittaHiroshi Ueno
Apr 25, 2007·World Journal of Gastroenterology : WJG·Bao-He ZhuChang-Hua Zhang
Jun 23, 2007·Cardiovascular & Hematological Disorders Drug Targets·George L TipoeMan-Lung Fung

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Citations

Mar 15, 2012·Drug Discovery Today·Yali ZhaoKejia Yi
Sep 13, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Jyh-Gang LeuYao-Jen Liang
Apr 5, 2012·Journal of the Science of Food and Agriculture·Salvatore Chirumbolo
Mar 23, 2012·Journal of Cellular and Molecular Medicine·Almudena Pino-ÁngelesFrancisca Sánchez-Jiménez
Apr 17, 2015·Immunological Reviews·Gustavo Pedraza-AlvaMasami Ando-Kuri
Jul 6, 2014·Food Chemistry·Jana OgnjenovićTanja Cirkovic Velickovic
Apr 14, 2016·Nutrients·Teresa VezzaJulio Galvez
Mar 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fei-Yan FanMin Jiang
Jan 1, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yanqiu WangNa Liu
Jul 7, 2017·Critical Reviews in Food Science and Nutrition·Lei ChenJianbo Xiao
Mar 22, 2012·Journal of Dietary Supplements·Shaida Fariza SulaimanTakayuki Shibamoto

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