Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex

Neuron
M ColledgeJ D Scott

Abstract

Compartmentalization of glutamate receptors with the signaling enzymes that regulate their activity supports synaptic transmission. Two classes of binding proteins organize these complexes: the MAGUK proteins that cluster glutamate receptors and AKAPs that anchor kinases and phosphatases. In this report, we demonstrate that glutamate receptors and PKA are recruited into a macromolecular signaling complex through direct interaction between the MAGUK proteins, PSD-95 and SAP97, and AKAP79/150. The SH3 and GK regions of the MAGUKs mediate binding to the AKAP. Cell-based studies indicate that phosphorylation of AMPA receptors is enhanced by a SAP97-AKAP79 complex that directs PKA to GluR1 via a PDZ domain interaction. As AMPA receptor phosphorylation is implicated in regulating synaptic plasticity, these data suggest that a MAGUK-AKAP complex may be centrally involved.

References

Apr 23, 2013·Pflügers Archiv : European journal of physiology·Kavisha AroraAnjaparavanda P Naren
Jul 19, 2006·Cell and Tissue Research·Laurent Groc, Daniel Choquet
Nov 19, 2003·Biochemical and Biophysical Research Communications·Rachel D GrothPaul G Mermelstein
Nov 19, 2003·Biochemical and Biophysical Research Communications·Kimberly L Dodge, John D Scott
Nov 19, 2003·Biochemical and Biophysical Research Communications·Isabelle M Mansuy
May 4, 2005·Molecular and Cellular Neurosciences·Erika SuzukiAmy C Arai
Feb 21, 2004·Neuropharmacology·Andrea L BaumanJohn D Scott
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Sep 15, 2001·European Journal of Pharmacology·A SharmaR C Deth
Oct 15, 2003·Neuron·George J AugustineKeiko Tanaka
Mar 8, 2002·Cellular Signalling·Eun Mi Hur, Kyong Tai Kim
Jun 12, 2001·Current Opinion in Neurobiology·S G Grant, T J O'Dell
Jun 7, 2002·Current Opinion in Neurobiology·Michael F Barry, Edward B Ziff
May 13, 2011·Biochemistry·Andrew V LeKimberly L Dodge-Kafka
Jan 27, 2009·Nature Neuroscience·Samarjit BhattacharyyaRobert C Malenka
Jul 12, 2005·Nature Neuroscience·Chong-Hyun KimR L Huganir
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·Wei Wong, John D Scott
Sep 21, 2004·Nature Reviews. Neuroscience·Eunjoon Kim, Morgan Sheng
Jun 2, 2005·Nature Reviews. Neuroscience·Mary B KennedyLorraine R Washburn
Jan 21, 2009·Nature Reviews. Neuroscience·Wei Feng, Mingjie Zhang
Jan 25, 2003·The European Journal of Neuroscience·A GéninV O'Connor
Nov 8, 2002·Journal of Neurochemistry·Hongbing WangDaniel R Storm
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brian J TunquistJohn D Scott
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew G GoldJohn D Scott
Aug 8, 2009·The Journal of Biological Chemistry·Hueng-Chuen FanPeter A McNaughton
Jun 10, 2010·The Journal of Biological Chemistry·Ravi VaidyanathanJustus M B Anumonwo
Apr 23, 2010·The Journal of Biological Chemistry·Debbie WilloughbyDermot M F Cooper
May 21, 2010·The Journal of Biological Chemistry·Michael W FriedrichOliver Griesbeck
Dec 16, 2010·The Journal of Biological Chemistry·Ian M Brooks, Steven J Tavalin
Sep 22, 2006·The Journal of Biological Chemistry·David A CantonDavid W Litchfield
Oct 30, 2013·The Journal of Cell Biology·Nathalia Vitureira, Yukiko Goda
Feb 28, 2003·Biology of Reproduction·Paula R BrownEdward M Eddy
Nov 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emile G BruneauMohammed Akaaboune
Apr 17, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dayong WangYang K Xiang
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roberto Malinow

Citations

Sep 1, 1981·The Journal of Cell Biology·R B ValleeW E Theurkauf
Oct 1, 1994·Trends in Neurosciences·J Lisman
Apr 1, 1996·Current Biology : CB·J M Anderson
Jun 1, 1997·Trends in Neurosciences·M B Kennedy
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Morgan Sheng, M Wyszynski
Feb 12, 1998·Science·T Pawson, J D Scott
Jan 14, 1998·Neuron·Edward B Ziff
May 26, 1998·The EMBO Journal·Mark L Dell'AcquaJ D Scott
Jul 25, 1998·The Journal of Biological Chemistry·A S LeonardJohannes W Hell
Aug 4, 1998·Current Opinion in Neurobiology·R J O'BrienR L Huganir
Oct 9, 1998·The Journal of Biological Chemistry·A KashishianY Lai
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·V A DerkachT R Soderling
Jun 4, 1999·Trends in Cell Biology·Marcie Colledge, J D Scott
Jun 11, 1999·The Journal of Biological Chemistry·A W McGee, D S Bredt
Jul 22, 1999·Annals of the New York Academy of Sciences·Morgan Sheng, D T Pak
Jul 22, 1999·Annals of the New York Academy of Sciences·H DongR L Huganir
Aug 17, 1999·Current Opinion in Cell Biology·A S Fanning, J M Anderson
Sep 18, 1999·Science·Robert C Malenka, R A Nicoll
Oct 8, 1999·The Biochemical Journal·M C FauxJohn D Scott
Feb 1, 2000·Trends in Neurosciences·T R Soderling, V A Derkach

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